Microwave sterilization

Dry heat is used to sterihze and depyrogenate components and drug products. The definition of dry heat sterilization is 170 °C for at least 2 hours and a depyrogenation cycle at 250 °C for more than 30 minutes. Typical equipment includes tunnel sterilizers (force convection, infrared, fiame) and microwave sterilizers. An important aspect is the need to ensure air supply is filtered through HEPA filters. Biological indicators such as Bacillus subtilis can be used to gauge the performance of sterilization. 

Ohlsson, T. and Bengtsson, N. 1975. Dielectric food data for microwave sterilization processing. Journal of Microwave Power. 10(1) 93-108. 

Abstract Biotextile sterilization presents unique challenges. The chapter describes the principles of sterilization and the way in which sterility assurance levels are defined and demonstrated.Traditional thermal, chemical and radiation sterilization methods are described, as well as newer methods such as plasma and microwave sterilization, and applications for which each is suitable. The advantages of the emerging technology of radiochemical sterilization are described, together with some of its successful applications, such as surgical sutures and tissue adhesive and the results of recent comparative studies of radiochemical and other sterilization methods for absorbable materials. Projected future trends in sterilization technology are also outlined. 

Microwave sterile glycerol for 30 s. Do not mix the glycerol so that the top portion remains as hot as possible. 

In either case, the time-temperature measurement within the moving food particulates is difficult, and consequently assuring commercial sterility without overprocessing is not a straightforward matter. In this p ier, we will discuss how thermally produced compoimds can be used as chemical markers of sterility in ohmic heating and microwave sterilization. 

The reported chemical markers are useful markers of sterility, which is an important quality index in shelf-stable foods. The use of the markers to map lethality distribution in particulate foods has been demonstrated. The markers can be used for validating and optimizing new thermal processing technologies such as ohmic heating and microwave sterilization. 

Microwave sterilization is a new method and it plays a significarrt role in synthesis (Honda et al., 1998 Sasaki et al., 1998a). The sterilization is brought about by microwave dielectric heating effect. The efficiency of a microwave sterilizer was... 

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