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Microparticles local delivery

Gradus-Pizlo I, Wilensky RL, March KL, et al. Local delivery of biodegradable microparticles containing colchicine or a colchicine analogue effects on restenosis and implications for catheter-based drug delivery. J Am Coll Cardiol 1995 26(6) 1549-1557. [Pg.313]

Local delivery Subcutaneously or intramuscularly applied microparticles can maintain a therapeutically effective concentration at the site of action for a desirable duration. The local delivery system obviates systemic drug administration for local therapeutic effects and can reduce the related... [Pg.2315]

Use of microparticle systems is not limited to the sustained or local delivery and has a wide range of applications. A limited number of examples are introduced below. [Pg.2324]

FIGURE 22.21 SEM images of PCL microparticles fabricated under different polymer solution flow rates (a) 3 mL/h, (b) 10 mL/h, and (c) 15 mL/h. (Reprinted from Biomaterials, 27, Xie, J., Marijnissen, J.C.M., and Wang, C.-H., Microparticles developed by electrohydrodynamic atomization for the local delivery of anticancer drug to treat C6 glioma in vitro, 3321-3332, Copyright 2006, with permission from Elsevier.)... [Pg.428]

Xie, J., J.C.M. Marijnissen, and C.-H. Wang. Microparticles developed by electrohydrodynamic atomization for the local delivery of anticancer drug to treat C6 glioma in vitro. Biomaterials 27(17) (2006) ... [Pg.434]

Gu L, Park J-H, Duong KH, Ruoslahti E, Sailor MJ (2010) Magnetic luminescent porous silicon microparticles for localized delivery of molecular drug payloads. Small 22 2546... [Pg.403]

Local delivery of microparticles with a biomaterial scaffold ... [Pg.245]

Rahimian S, Fransen MF, Kleinovink JW, Amidi M, Ossendorp F, Hennink WE. Polymeric microparticles for sustained and local delivery of antiCD40 and antiCTLA-4 in immunotherapy of cancer. Bioniaterials 2015 61 33-40. [Pg.264]

Masters and Domb [250] reported on an injectable drug delivery system that uses liposomes [251] to release the local anesthetic, bupivacaine, from a liposomal matrix that is both biodegradable and biocompatible to produce SLAB. Bupivacaine due to its minimum vasodilating properties was preferred to other local anesthetics (e.g., lidocaine) allowing the released drug to remain at the site of injection longer [252]. Lipospheres are an aqueous microdispersion of water insoluble, spherical microparticles (0.2 to 100 pm in diameter), each consisting... [Pg.89]

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See also in sourсe #XX -- [ Pg.2315 ]



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