Microparticles Encapsulation

In general, compared to irregular xerogel matrix particles, microparticles encapsulate a far higher load of active ingredient (up to 90% in weight of the final materials), and afford a wide control over the release rate (from hours to months and up to unlimited retention of the entrapped ingredient), thanks to control of the microstructure and thus by the initial sol-gel chemistry. 

EXPERIMENT—AN EXAMPLE PRODUCTION OF CARNAUBA WAX MICROPARTICLES ENCAPSULATING ETHYL VANILLINE... 

Janet T, Taylor JRN, Belton PS, Amanda M. KaUrin microparticle encapsulation of catechin and sorghum condensed tannins. J Agric Food Chem. 2009 57(16) 7523—7528. 

Holland, T. A., Tabata, Y, Mikos, A.G., 2003. In vitro release of transforming growth factor-beta 1 from gelatin microparticles encapsulated in biodegradable, injectable ohgo(poly(eth-ylene glycol) fumarate) hydrogels. Journal of Controlled Release 91, 299-313. 

Dass, CR Contreras, KG Dunstan, DE Choong, PPM. Chitosan microparticles encapsulating PEDF plasmid demonstrate efficacy in an orthotopic metastatic model of osteosarcoma. Biomaterials, 28 (19), 2007, 3026-3033. 

LS and CLS are solid microparticles with a mean diameter usually between 0.2 and 500 pm, composed of a solid hydrophobic fat matrix in which (in the case of LS) the bioactive compound or compounds are dissolved or dispersed. Because of their large range in particle size, LS can be administered by different routes, such as orally, subcutaneously, intramuscularly, or topically, or they can be used for cell encapsulation, thus allowing them to be proposed for treatment of a number of diseases [26-28], The in vivo distribution of LS demonstrated a high affinity to vascular wells (including capillaries), to inflamed tissues, and to granulocytes [29,30],... 

In this respect, an interesting approach to reduce degradation and possible toxicity problems related to nucleic acid use in vivo is offered by their encapsulation in or association to microcarrier systems, such as neutral or cationic liposome and polymeric microparticles [41 14],... 

As above reported, among microparticles, CLS have been proposed as a new type of fat-based encapsulation system developed for drug delivery of bioactive compounds. 

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