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Microglia, and Dendritic Cells

The p35 subunit of IL-12 is produced by T and B cells, NK cells, neutrophils, monocytes, and macrophages (at least in the mouse). The p40 subunit is produced mainly by B lymphocytes, activated monocytes, and dendritic cells (including epidermal Langerhans cells). Consequently the principal sources of IL-12 are B cells and monocytes and/or macrophages (Figure 22-20). In the brain, microglia-like cells are the primary producers of the p40 transcripts. In contrast, the IL-12 p35 gene is constitutively expressed in the brain at a very low level. ... [Pg.682]

Dendritic cells of skin and lymph nodes Brain microglia... [Pg.448]

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Dendrite cells

Dendritic cell

Microglia cell