Microfluidic fundamentals

Pumera, M. and Escarpa, A. (2009) Nanomaterials as electrochemical detectors in capillary electrophoresis and microfluidics fundamentals, designs and applications. Electrophoresis, 30, 3315-3323. 

In this chapter we first discuss the fundamentals and the design aspects of an integrated optical YI sensor (Sect. 10.2), followed by a description of the experimental setup (Sect. 10.3). In the result section (Sect. 10.4) both protein and vims detection experiments are discussed. Section 10.5 demonstrates the use of microfluidic chips for efficient sample handling in combination with the YI sensor. This chapter concludes with a discussion on the prospects of the sensor for point-of-care diagnostics. 

The book is intended to provide a useful summary of the various electroki-netic phenomena that play a fundamental role in the various methods and applications mentioned above. In addition to serving as a reference book for analytical chemists in pharmaceutical and biotechnology companies, the material should be helpful to graduate students in many disciplines including chemistry, pharmacy, biochemistry, chemical engineering, and microfluidics. 

While the most obvious advantage of microfluidics is the enormous reduction in sample consumption, the growth of protein crystals can also be fundamentally improved by taking advantage of the physical properties of fluid flow at the mi-... 

N. -T. Nguyen and S. Wereley, Fundamentals and Applications of Microfluidics, Artech House, Boston, MA, 2006. 

Young, E.W.K. and Beebe, D.J. (2010) fundamentals of microfluidic cell culture in controlled... 

S. Kaka9 et al. (eds.), Microfluidics Based Microsystems Fundamentals and Applications, DOI 10.1007/978-90-481-9029-4 1, Springer Science + Business Media B.V. 2010... 

R.M. Cotta, S. Kakag, M.D. Mikhailov, F.V. Castellos, and C.R. (Tardoso, Transient flow and thermal analysis in microfluidics, Microscale Heat Transfer-Fundamentals and Applications in Biological Systems and MEMS, edited by... 

Abstract. The lecture will review the recent advances in the techniques for formation of bubbles of gas and droplets of liquid in two-phase microfluidic systems. Systems comprising ducts that have widths of the order of 100 pm produce suspensions of bubbles and droplets characterized by very narrow size distributions. These systems provide control over all the important parameters of the foams or emulsions, from the volumes of the individual bubbles and droplets, through the volume fraction that they occupy, the frequency of their formation, and the distribution of sizes, including monodisperse, multimodal and non-Gaussian distributions. The lecture will review the fundamental forces at play, and the mechanism of formation of bubbles and droplets that is responsible for the observed monodispersity. 

In this chapter, the fundamentals of the front-tracking method are described as a computational method that can be used as a design tool in microfluidic systems. 

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