Microfibrillar collagen

Microfibrillar collagen hemostat Microfibrillar collagen hemostat is synthesized from cow collagen. It is used for surgical intervention as an adjuvant drug for bleeding when other procedures are ineffective and impractical. A synonym of this drug is avitene. 

Those membranes, however, have a drawback as a second surgical entry is needed to remove the membrane after tissue regeneration has been achieved, if the membranes are not biodegradable. In order to preclude the surgical removal of an implant after doing its task, membranes made of bioabsorbable material, such as microfibrillar collagen, PLA, and poly(galactin) have been used. 

Scher, K.S. and Coil, J.A. Jr (1982) Effects of oxidized cellulose and microfibrillar collagen on infection. Surg., 91, 301-4. 

In contrast, collagen absorbable hemostatic sponges are sterilized either by exposure to ethylene oxide gas, y-rays, dry heat or an electron beam. CollastaH is an example of a material that is sterilized by exposure to ethylene oxide gas and Avitene is a microfibrillar collagen hemostat that is sterilized by exposure... 

VIedchem Products Avitene (Microfibrillar collagen) Hemostat Nonwoven Web Hemostat 08/26/76... 

Tanner,. M.G., Solt, C.W. and Vuddhakanok, S. (1988) An evaluation of new attachment formation using a microfibrillar collagen barrier./. Peiiodontol, 59, 524—530. 

Microfibrillar collagen is an excellent hemostat agent used in several studies in order to prepare biomaterials for pharmaceutical and medical application [19]. The hemostatic character of collagen is manifested when the platelets in contact with collagen material adhere to its surface, desorb and aggregate and activate the thrombin in fibrinogen, which ends with the appearance of thrombus. 

The embolic agents most commonly used for splenic ablation are Gelfoam pledgets and polyvinyl alcohol particles. Yoshioka et al. [105] also showed excellent increases in platelet counts when coils were placed within the intrasplenic branches, and Hickman et al. [108] successfully used Gel-foam, polyvinyl alcohol particles, and coils alone or in combination for preoperative embolization. In animal studies, additional materials that have been used for this purpose are absolute ethanol [121,122], microfibrillar collagen [123], tissue adhesives [124], balloon catheters [125], silicone particles [126], and... 

Rybock, J.D. and Long, D.M. 1977. Use of microfibrillar collagen as a topical hemostatic agent in brain tissue. J. Neurosurg. 46 501-505. 

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