Microfibrillar collagen hemostats

Microfibrillar collagen hemostat Microfibrillar collagen hemostat is synthesized from cow collagen. It is used for surgical intervention as an adjuvant drug for bleeding when other procedures are ineffective and impractical. A synonym of this drug is avitene. 

In contrast, collagen absorbable hemostatic sponges are sterilized either by exposure to ethylene oxide gas, y-rays, dry heat or an electron beam. CollastaH is an example of a material that is sterilized by exposure to ethylene oxide gas and Avitene is a microfibrillar collagen hemostat that is sterilized by exposure... 

VIedchem Products Avitene (Microfibrillar collagen) Hemostat Nonwoven Web Hemostat 08/26/76... 

Microfibrillar collagen is an excellent hemostat agent used in several studies in order to prepare biomaterials for pharmaceutical and medical application [19]. The hemostatic character of collagen is manifested when the platelets in contact with collagen material adhere to its surface, desorb and aggregate and activate the thrombin in fibrinogen, which ends with the appearance of thrombus. 

Rybock, J.D. and Long, D.M. 1977. Use of microfibrillar collagen as a topical hemostatic agent in brain tissue. J. Neurosurg. 46 501-505. 

Today collagen as a hemostatic agent exists in the microfibrillar form, as a nonwoven fleece or as a sponge produced by the technique of freeze-drying. The physical structure of a sponge offered as a sheet has certain additional characteristics to serve as an effective hemostatic device with excellent handling. 

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