Microbial Production of 3-Hydroxypropionic Acid

Yokimiko David, Young Hoon Oh, Mary Grace Baylon, Kei-Anne Baritugo, Jeong Chan Joo, Cheol Gi Chae, You Jin Kim, and Si Jae Park  

3-HP can be synthesized from P-propiolactone, acryhc acid, and P-hydroxypropionitrile. Similar to other conventional chemical syntheses, this process also requires the use of either toxic starting materials and catalysts, or expensive raw materials. Several studies have presented a green method for 3-HP synthesis through catalytic reactions, which include the oxidation of 1,3-PDO and 3-hydroxypropanal, carbonylation of vinyl acetate, and oxidation of allyl alcohol [2]. The limited quantities of the starting materials, formation of intermediates, the toxicity caused by the catalyst, expensive substrates, and the selectivity of the catalytic processes for 3-HP production are the problems that must be surpassed in order to meet the requirements for commercialization. 

There are still no industrially feasible biological processes for efficient 3-HP production [9], since the microbial fermentation process could not reach the minimum 3-HP productivity ( 2.5gl h ) that is thought to be economically 

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Microbial Production of 3-Hydroxypropionic Acid From Renewable Sources A Green Approach as an Alternative to Conventional Chemistry... 

MICROBIAL PRODUCTION OF 3-HYDROXYPROPIONIC ACID FROM RENEWABLE SOURCES... 

Microbial Production of 3-Hydroxypropionic Acid from Renewable Sources A Green Approach as an Alternative to Conventional Chemistry, in Bioprocessing of Renewable Resources to Commodity Bioproducts (eds V. S. Bisaria and A. Kondo), John Wiley Sons, Inc., Hoboken, NJ, USA. 

Matsakasa, L., Topakasa, T., Ghristakopoulosb, P., 2014. New trends in microbial production of 3-hydroxypropionic acid. Gurrent Biochemical Engineering 1,141-154. 

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