Microarrays advantages

The possibility of customization is the principal scientific advantage of the system. The microarray design, layout, and format are specific for each scientist s needs and objectives. The Design-on-Demand service offer by CombiMatrix try to cover this versatility. The researcher, though would define his experimental strategy with CombiMatrix support. Available libraries include eukaryotic, microbial, and viral genomes. Direct customer services are also offered. 

The main advantage of this experimental design is that both samples are compared on a single DNA microarray, and therefore errors that are due to the use of multiple microarrays, such as variation in microarray production, hybridization, and washing, are minimized. Time and money considerations are another important advantage of this design. 

An array or a matrix of nucleic acid probes immobilized at discrete locations on a silicon or glass surface provides a convenient means to simultaneously probe a sample for the presence of many different target sequences. Microarray biochip scanning devices, mostly based on fluorescent labels, are now currently available, and could also be used with CL labels to take advantage of the higher sensitivity of this detection principle. 

However, in addition to its low production costs and excellent gas analytical features, the gradient microarray chip offers further advantages over the classical arrays consisting of separate gas sensors of different chemistry. Since all sensor ele-... 

DNA microarrays offer the advantage of sensitivity, flexibility in the choice of genes for analysis, and power of analysis if combined with appropriate bioinformatics tools. Using DNA microarrays, the expression of thousands of genes can be measured simultaneously and in a high-throughput manner. 

We may also find that Sabatini s reverse transfection method of creating "live cell" microarrays offers even greater advantage for drug discovery and development (Ziauddin and Sabatini, 2001). Their method, relying on arrayed cDNA expression vectors to transform adherent cells, provides localized real-time gene expression analysis of the putative gene product. 

Pierce introduced an array-of-arrays microplate product called Search-Light in which antibodies are directly printed into the wells of the microplate. Also, we have reviewed MSD s Multi-Spot plate products having antibodies immobilized onto multiple working electrodes. These products (albeit with some novel approaches to create microarrays and means for detection) utilize the classic immunosorbent sandwich assay but have the advantage of parallel processing using microarrays. 

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