Microangiopathic disease

Cerebral microangiopathic disease - also termed small-vessel or white-matter disease, leukoaraio-sis and subcortical vascular encephalopathy (SVE)... 

The clinical features of microangiopathic disease are increasingly better understood. This increase in knowledge on characteristic clinical types of cognitive worsening and their morphological correlates starts to improve the early identification of affected... 

Finally, the successful use of vincristine in the treatment of drug-induced microangiopathic hemolytic anemia, a disease resembling the hemolytic uremic syndrome rarely seen subsequent to administration of mitomycin C or other chemotherapy has been described in two patients with this disorder (79). 

The natural history of the disease is determined by the onset and extent of chronic diabetic complications. Microangiopathic changes are diabetes-specific, causing retinopathy, nephropathy and alterations in the peripheral and autonomous nervous system. Macroangiopathy, which is more typical for Type-II diabetes, leads predominantly to cardiovascular complications with coronary heart disease, myocardial infarction and peripheral vascular occlusion. 

Lockey et al. (1987) described a 47-year-old woman with previously excellent health who developed fatal SSc after a single 2.5-h predominantly dermal exposure to trichloroethylene. During a period of 10 months, the patient developed proximal scleroderma, reflux esophagitis, microangiopathic hemolytic anemia, restrictive pulmonary disease, pericarditis with effusion, and renal insufficiency with severe hypertension. Renal and skin biopsies were consistent with SSc. An additional case of SSc in a 51-year-old female worker has been presented, who developed SSc after 15 years of exposure to perchloroethylene (Szeimies et al. 1992). 

---