Micro satellite markers

Escamilla et al. (86), in a study of bipolar mood disorder in an isolated population from Costa Rica, using micro satellite markers spaced 6cM intervals across chromosome 18, concluded that LD methods will be useful in this case in a larger sample. The Finnish and Costa Rican populations are considered ideal, since they are relatively homogeneous and show LD over a wider recombination distance than other populations. However, LD is routinely seen for closely linked loci and around disease genes in all populations. With sufficiently closely linked markers, including haplotype level analyses (61,62), association mapping should be a powerful and informative approach in many, and possibly most, populations (57). 

Proschowsky et al. (2000) have developed a diagnostic test based on the micro satellite marker C04107 for copper toxicosis in Bedlington terriers described by Yuzbasiyan et al. (1997). Until now, this test has to be considered the best tool that breeders of Bedlington terriers can use in the eradication of copper toxicosis, as surveys carried out so far have indicated that the genetic basis for the disease is similar both in Europe and in the USA. 

Hicks, M., D. Adams, S. O Keefe, E. Macdonald and R. Hodgetts. 1998. The development of RAPD and micro satellite markers in lodgepole pine (Pinus contorta var. latifolia). Genome 41 797-805. 

Hodgetts, R.B., M.A. Aleksiuk, A. Brown, C. Clarke, E. MacDonald, S. Nadeem and D. Khasa. 2001. Development of micro satellite markers for white spruce Picea glauca) and related species. Theor. Appl. Genet. 102 1252-1258. 

Li, C., Erwin, A., Pap, D., Coleman, C., Higgins, A.D., Kiss, E., Kozma, R, Hoffmann, S., Ramming, D.W., Kovacs, L.G., 2013. Selection for Runl-Renl dihybrid grapevines using micro satellite markers. Am. J. Enol Vitic 64, 152-155. 

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