Michaelis continuous stirred-tank reactor

With respect to benzaldehyde, (R)-oxynitrilase exhibits saturation kinetics (Michaelis Menten kinetics, see Sect. 7.4.2.1) and a maximum reaction rate is reached above a concentration of about 5 mmol L 1. The chemical reaction presents a linear increase of the reaction rate with increasing benzaldehyde concentration, representing first order kinetics, when the concentration of HCN is kept constant (see Fig. 7-13). As a consequence the enzymatic reaction becomes more dominating at lower concentrations of the substrate benzaldehyde (for HCN as substrate the same kinetic behavior occurs, data not shown). Accordingly an enzyme reactor would be suitable that works under minimum average substrate concentrations. These requirements are satisfied by the continuous stirred tank reactor (CSTR). In Sect. 7.5.2.1 this aspect of enzyme reaction engineering will be discussed further. 

M-M Michaelis-Menten Cl competitive inhibition NCI non-competitive inhibition UCl uncompetitive inhibition CPBR continuous packed-bed reactor BSTR batch stirred-tank reactor CSTR continuous stirred-tank reactor... 

Thus, for Michaelis-Menten kinetics, a PFR type reactor, predominantly a packed-bed reactor (PBR, Figure 9.1b) is preferred to the continuous stirred-tank reactor (CSTR, Figure 9.1a), since it requires less biocatalyst to reach the same level of conversion. In this case, ideal reactors are those with high space time/yield to increase the efficiency of the transformation. PBRs with immobilized catalyst have a clear advantage in that voidage is low 34% compared to over 80-90% for CSTR [35]. However, if pH control is required, the use of a PFR is not advised. In case of substrate inhibition, a CSTR (Figure 9.1a) operated at high conversion is to be preferred. On the other hand, when product inhibition is pronounced, a... 

ASME CFSTR CFD CFM DIERS exp IR HA/AN HAZOP MM MMM American Society of Mechanical Engineers Continuous flow stirred tank reactor Computational fluid dynamics Computational fluid mixing Design Institute for Emergency Relief Systems exponential Infrared (spectroscopy) Hazard analysis Hazard and operability studies Michaelis-Menten Maximum-mixedness model... 

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