Micelles, thermoresponsive

Water-soluble thermoresponsive PNIPAM and PMVE blocks have been associated to hydrophobic blocks [140,141], Micelles have been prepared in water in which the hydrophobic core is surrounded by PMVE or PNIPAM... 

Thermoresponsive Polymeric Micelles for Double Targeted Drug Delivery... 

Scheme 2 Thermoresponsive polymeric micelle structures and fimctions.

ON-OFF SWITCHABLE DRUG RELEASE FROM THERMORESPONSIVE POLYMERIC MICELLES... 

Figure 4 Drug (ADR) release from thermoresponsive PIPAAm-PBMA micelles containing ADR [27]. 

Figure 6 In vitro cytotoxicity of free ADR (0.1 jxg/mL) and thermoresponsive PIPAAm-PBMA micelles containing ADR (0.1 jxg/mL) against bovine aorta endodieUal cells at 29°C (below the LCST) and 37°C (above the LCST). Incubation time 4 days.

Thermoresponsive polymeric micelles with PIPAAm block copolymers can be expected to combine passive spatial targeting specificity with a stimuli-responsive targeting mechanism. We have developed LCSTs of PIPAAm chains with preservation of the thermoresponsive properties such as a phase transition rate by copolymerization with hydrophobic or hydrophilic comonomers into PIPAAm main chains. Micellar outer shell chains with the LCSTs adjusted between body temperature and hyperthermic temperature can play a dual role in micelle stabilization at a body temperature due to their hydrophilicity and initiation of drug release by hyperthermia resulting from outer shell structural deformation. Simultaneously, micelle interactions with cells could be enhanced at heated sites due... 

Scheme 4 Drug action mechanisms of thermoresponsive polymeric micelles.

Scheme 5 Double targeting with both passive and stimuli-responsive manners by thermoresponsive polymeric micelles.

Cammas, S., K. Suzuki, Y. Sone, Y. Sakurai, K. Kataoka, and T. Okano. 1997. Thermoresponsive polymer nanoparticles with a core-shell micelle structure as site sped c drug cadrifientrol. Rel.48 ... 

Thermoresponsive polymers based on oligo(ethylene glycol) acrylates or methacrylates can be easily prepared by atom transfer radical polymerization under straightforward experimental conditions (i.e. in bulk or in ethanol solution and in the presence of commercially available catalysts). Thus, these stimuli-responsive macromolecules can be exploited for preparing a wide range of smart advanced materials such as thermoreversible hydrogels, thermoresponsive block-copolymer micelles and switchable surfaces. Hence, some of the results... 

WEI Wei, H., Zhang, X.-Z., Zhou, Y., Cheng, S.-X., and Zhuo, R.-X., Self-assembled thermoresponsive micelles of poly(A-isopropylacrylamide-Z)-methyl methacrylate). Biomaterials, 27, 2028, 2006. 

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