Miacalcin Nasal

Calcitonin (Miacalcin, Miacalcin Nasal Spray) is a synthetic 32-amino acid polypeptide that is identical to salmon calcitonin. Salmon calcitonin is more potent than human calcitonin because of its higher affinity for the human calcitonin receptor and its slower metabolic clearance. Administration is by subcutaneous or intramuscular injection or by nasal spray. The absorption of the nasal form is slower than that of the parenteral routes. 

Brand Name(s) Calcimar, Cibacalcin, Fortical, Miacalcin, Miacalcin Nasal CfiemicalClass Polypeptide hormone... 

Nasal Spray (Fortical, Miacalcin Nasal) 200 international units/activation (calcitonin-salmon). 

Miacalcin Nasal Spray. Novartis Pharmaceutical Corp. East Hanover, NJ (1998). Package Insert. 

MIACALCIN nasal spray Novartis (U.S.) Calcitonin-salmon 32 amino acids, Mr = 3527 BKC 0.1 mg/mL, NaCI 8.5 mg/mL, HCI, N2 Glass bottles, screw-on pump 90 pL per actuation... 

American Pharmaceutical Association. New Product Bulletin. Miacalcin Nasal Spray. Washington, DC,... 

On February 17,2004, Nastech Pharmaceutical Company announced its filing of an ANDA for a salmon calcitonin nasal spray drug product for the treatment of postmenopausal osteoporosis. As with Fortical, Novartis s Miacalcin was cited as the reference listed drug however, Nastech chose to submit an ANDA via the 505(j)(l) route, rather than a 505(b)(2) application. 

Calcitonin (Miacalcin) 200 units daily, intranasally (alternating nares every other day) 3% nasal availability renal elimination Rhinitis, epistaxis None... 

Calcitonin (Calcimar [IV, SC] Miacalcin and Fertical [nasal spray])... 

Commercially available peptide hormones delivered as nasal spray solutions include Synarel (nafare-lin), Stimate NS (desmopressin), Suprefact (buserelin acetate), and Miacalcin (salmon calcitonin). A list of current drugs in the market, doses, and bioavailability along with a comparative bioavailability profile for oral desmopressin is presented in Table 86.3. 

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