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Metoprolol enantiomers

The efficiency of many CSPs increases dramatically when liquid eluents are replaced with sub- or supercritical fluids. During a comparison of LC and SFC performed with a Chiralcel OD CSP, Lynam and Nicolas reported that the number of theoretical plates obtained was three to five times higher in SFC than in LC [26]. The separation of metoprolol enantiomers by LC and SFC on a Chiralcel OD CSP is illustrated in Fig. 12-2. Although impressive selectivity is achieved by both techniques, resolution is higher in SFC (R = 12.7) than in LC (R = 4.8), and the higher flowrate in SFC reduces the analysis time. The increased efficiency of SFC also improves peak symmetry. [Pg.304]

Fig. 12-2. Separation of metoprolol enantiomers by LC and SFC on a Chiralcel OD CSP. Chromatographic conditions for LC 20% 2-propanol in hexane, with 0.1 % diethylamine, 0.5 mL min f Chromatographic conditions for SFC 20 % methanol with 0.5 % isopropylamine in carbon dioxide, 2.0 mL min 15 MPa, 30 °C. Fig. 12-2. Separation of metoprolol enantiomers by LC and SFC on a Chiralcel OD CSP. Chromatographic conditions for LC 20% 2-propanol in hexane, with 0.1 % diethylamine, 0.5 mL min f Chromatographic conditions for SFC 20 % methanol with 0.5 % isopropylamine in carbon dioxide, 2.0 mL min 15 MPa, 30 °C.
Kim, K.H., Kim, H.J., Kang, J.-S., Mar, W. (2000b). Determination of metoprolol enantiomers in humanurineby coupled achiral-chiral chromatography. J. Pharm. Biomed. Anal. 22,377-384. [Pg.342]

Metoprolol enantiomers/urine HPLCMS Column Chirobiotic T (250 x 4.6 mm, 5 pm) Mobile phase MeOH CH3COOH NH3 (100 0.15 0.15 v/v/v) (isocratic elution) Detection MS, ionization ESI Extraction LLE/ethyl acetate LOQ 0.5 ng/mL [60]... [Pg.269]

The separation of the metoprolol enantiomers was performed on a i-acid-glycoprotein column (100 mm x 4 mm ID) (ChromTech AB, Stockholm, Sweden) with a mobile phase of 0.25% 2-propanol in 20 mmol/1 phosphate buffer (pH=7) at a flow-rate of 0.8 ml/min. [Pg.180]

Figure 5. Peaks of the (+)- and (-)-metoprolol enantiomers after chiral separation, phase-system switching and moving belt LC/MS. Conditions see text. Figure 5. Peaks of the (+)- and (-)-metoprolol enantiomers after chiral separation, phase-system switching and moving belt LC/MS. Conditions see text.
Herring, V.L. Bastian, T.L. Lalonde, R.L. Solid-phase extraction and direct high-performance liquid chromatographic determination of metoprolol enantiomers in plasma. J.Chromatogr., 1991, 567, 221-227... [Pg.890]

Straka, R.J. Johnson, K.A. Marshall, P.S. Remmel, R.P. Analysis of metoprolol enantiomers in human serum by liquid chromatography on a cellulose-based chiral stationary phase. J.Chromatogr., 1990, 530, 83-93... [Pg.892]

Leloux, M.S. Rapid chiral separation of metoprolol in plasma—appUcation to the pharmacokinet-ics/pharmacodynamics of metoprolol enantiomers in the conscious goat. Biomed.Chromatogr., 1992, 6, 99-105... [Pg.909]

Schuster, D. Modi, M.W. Lalka, D. Gengo, F.M. Reversed-phase high-performance liquid chromatographic assay to quantitate diastereomeric derivatives of metoprolol enantiomers in plasma. J.Chromatogr., 1988, 433, 318-325... [Pg.909]

Walhagen A, Edholm L-E, Heeremans GEM et at (1989) Coupled-column chromatography-mass spectrometry. Thermospray liquid chromatographic-mass spectrometric and liquid chromatographic-tandem mass spectrometric analysis of metoprolol enantiomers in plasma using phase-system switching. Journal of Chromatography 474 257. [Pg.849]

See other pages where Metoprolol enantiomers is mentioned: [Pg.344]    [Pg.269]    [Pg.279]    [Pg.167]    [Pg.175]    [Pg.179]    [Pg.466]    [Pg.215]    [Pg.285]   
See also in sourсe #XX -- [ Pg.529 ]



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