Methylprednisolone properties

Corticosteroids (dexamethasone, methylprednisolone) have antiemetic properties, but the basis for these effects is unknown. These agents are commonly used in combination with other agents in the... 

There is also evidence that the neuroprotective properties of lipid-peroxidation-inhibiting doses of methylprednisolone, extensively studied in spinal-cord injury, are applicable to brain injury. The steroid has been shown to enhance the early recovery of mice subjected to a moderately severe concussive head injury when administered at 5 minutes post-injury [59], The dose-response curve for this effect is remarkably similar to that discussed above for spinal-cord injury. A 30mg/kg i.v. dose was observed to be optimal, while lower (15 mg/kg) and higher (60 and 120 mg/kg) doses were ineffective. 

B Methylprednisolone. Given the patient s electrolyte abnormalities, all of the other corticosteroid options would be ruled out since they have mineralocorticoid effects that may make this patient s electrolyte abnormalities worse. Methylprednisolone has anti-inflammatory properties and no mineralocorticoid activity. 

A possible explanation for the anti-inflammatory action of cortisol based on the prevention of release of plasma kinins has been published. A number of 8-dehydro analogs of corticosteroids have been synthesized and their thymolytic and salt retaining properties measured. The compound found to have the highest thymolytic activity was 1 (11.4 x hydrocortisone). Again the fallacy of projecting biological activity from one series of steroids to another was demonstrated by the large decrease in activity exhibited by the 8-dehydro steroid 2 as compared with 16a-methylprednisolone (3). 

Methylprednisolone is an intermediate-acting glucocorticoid with no mineralocorticoid properties (see also Tables 11 and 14). Glucocorticoids are used in ... 

Methylprednisolone, a glucocorticoid with antiinflammatory and immunosuppressant properties, is used in the treatment of severe inflammation or immunosuppression. In addition, methylprednisolone has been used in the treatment or minimization of motor/sensory defects caused by acute spinal cord injmy (see also Tables 11 and 14). 

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