Methylprednisolone Aminophylline

Clinically important, potentially hazardous interactions with alfentanil, aminophylline, amisulpride, amoxicillin, ampicillin, anticonvulsants, astemizole, atorvastatin, benzodiazepines, bromocriptine, buprenorphine, bupropion, carbamazepine, cilostazol, ciprofloxacin, cisapride, clindamycin, colchicine, cyclosporine, dasatinib, digoxin, dihydroergotamine, diltiazem, disopyramide, enoxacin, eplerenone, ergotamine, eszopiclone, everolimus, fluconazole, fluoxetine, fluvastatin, gatifloxacin, HMG-CoA reductase inhibitors, imatinib, itraconazole, ketoconazole, lomefloxacin, lorazepam, lovastatin, methadone, methylprednisolone, methysergide, midazolam, mizolastine, moxifloxacin, nitrazepam, norfloxacin, ofloxacin, paroxetine, pimozide, pravastatin, quinolones, ranolazine, repaglinide, rupatadine, sertraline, sildenafil, simvastatin, sparfloxacin, sulpiride, tacrolimus, terfenadine, triazolam, troleandomycin, vardenafil, verapamil, vinblastine, warfarin, zaleplon, zolpidem, zuclopenthixol... 

Clinically important, potentially hazardous interactions with aminophylline, anticonvulsants, aprepitant, bedomethasone, bosentan, budesonide, cigarette smoking, danazol, efavirenz, exenatide, flucloxacillin, flunisolide, fluticasone, hydrocortisone, insulin detemir, lamotrigine, licorice, lymecycline, methylprednisolone, modafinil, nelfinavir, prednisolone, prednisone, rifabutin, rifampin, ritonavir, saw palmetto, selegiline, St John s wort, triamcinolone, troleandomycin, tuberculostatics, ursodeoxycholic acid, zolmitriptan... 

Noninterfering aminophylline, beclomethasone, cloprednol, dexamethasone, fenoterol, ipratropium bromide, methylprednisolone, orciprenahne, prednisolone, reproterol, limi-terol, salmeterol, sodium cromoglycate, theophylline... 

An infusion of isoprenaline increased the clearance of theophylline (given as intravenous aminophylline) by a mean of 19% in 6 children with status asthmaticus and respiratory failure. Two of them had increases in clearance of greater than 30%. Another study in 12 patients with status asthmaticus found that an isoprenaline infusion (mean maximum rate 0.77 micrograms/kg per minute) caused a mean fall in serum theophylline levels of almost 6 micrograms/mL. The levels rose again when isoprenaline was stopped. A critically ill patient receiving intravenous aminophylline, phenytoin and nebulised terbutaline had a marked 4.5-fold increase in theophylline clearance when an isoprenaline infusion and intravenous methylprednisolone were added to the regimen. ... 

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