Methylphosphonic diphenyl ester

Amino Acids and Peptides. - Wasserman s method of one-carbon homologation of carboxylic acids to give a-ketocarboxylates involves reaction with cyanomethylenetriphenyl-phosphorane followed by ozone (Scheme 24) and has been used as a key step in a chemo-enzymatic synthesis of isotopically labelled L-valine, L-isoleucine, and o/fo-isoleucine. Alkylation of the carbanion derived from the imino-substituted methylphosphonate diphenyl ester (186) with indol-3-ylmethyl bromide followed by appropriate deprotection has been used to prepare the phosphonate analogue (187) of tryptophan (Scheme 25). The deprotected analogue (188) and derived peptides show activity as inhibitors of chymotrypsin. Two approaches to solid phase Wadsworth-Enunons reactions which have applications in combinatorial chemistry have been reported. In one diethylphosphonoacetamide is bound to PEG-PAL resin via a peptide link, while... 

SYNS DIPHENYL METHANEPHOSPHONATE DIPHENYL METHYLPHOSPHONATE PHOSPHONIC ACID, METHYL-, DIPHENYL ESTER SAFETY PROFILE A poison by ingestion. When heated to decomposition it emits toxic vapors of POx. 

The third most commonly used class of flame-retardants is phosphorus-containing compounds such as phosphoric acid esters, diphenyl cre-sylphosphate, dimethyl methylphosphonate, and dibutyl dihydroxyethyl diphosphate. They have good flame-retarding performance and are effective in small amounts. They are, however, expensive and have low hydrolysis stability. 

The reaction of diphenyl methylphosphonate with lithium alkoxides gives phenyl alkyl methylphosphonates even with hindered alcohols and, in the case of chiral alcohols, with high diastereoselectivity at phosphorus. [Hydroxy(pho-sphoryloxy)X, iodo]benzenes 289, prepared from reactions of iodosobenzene with phosphonic or phosphinic acids react with ketones, esters or phenyl acetylene to give esters 290. Racemic l-hydroxy-4-(3-phenoxyphenyl)butylphosphonate diethyl ester undergoes stereoselective acetylation in the presence of a lipase to... 

Two convenient approaches to (diphenylphosphono)acetic esters (258) have been reported. One approach involves the reaction of chloroformate esters with the carbanion of diphenyl methylphosphonate and the other a Michaelis-Becker reaction of bromoacetic esters (Scheme 41) the former reaction gives better yields than the latter. Olefination reactions of (258) with benzaldehyde and... 

Tetrabromobisphenol A di-2-hydroxyethyl ether Tetradecabromodiphenoxybenzene Tetrakis (2-chloroethyl) ethylene diphosphate Tris (2,3-dichloropropyl) phosphate flame retardant, EPS Tribromophenyl allyl ether flame retardant, ethyl cellulose Diphenyl octyl phosphate flame retardant, ethylene copolymers Ethylenebis (tetrabromophthalimide) flame retardant, expandable PS Dibromoethyidibromocyclohexane Tetrabromobisphenol A bis (allyl ether) Tetrabromocyclooctane flame retardant, extruded PS Tetrabromocyclooctane flame retardant, fabrics Antimony pentoxide Methylphosphonic acid, (5-ethyl-2-methyl-2-oxido-1,3,2-dioxaphosphorinan-5-yl) methyl methyl ester flame retardant, fibers Antimony pentoxide Tetrabromoethane flame retardant, filament winding Epoxy resin, brominated flame retardant, film Tetrabromobis (2-ethylhexyl) phthalate flame retardant, fire-retardant material Chlorinated paraffins (C12, 60% chlorine) Chlorinated paraffins (C23, 43% chlorine) flame retardant, flexible PU foam bedding Tetrakis (2-chloroethyl) ethylene diphosphate flame retardant, flexible PU foam furniture Tetrakis (2-chloroethyl) ethylene diphosphate flame retardant, flexible PU foam transportation Tetrakis (2-chloroethyl) ethylene diphosphate flame retardant, flexible PU foams furniture, automobile seating... 

Condensation Polymerization of Phosphonate Esters or Diamides with Diamines and Related Reactions. Treatment of diphenyl methylphosphonate with diamines produces thermoplastic materials with elemental compositions corresponding to polymeric phosphonamides or imides (102,147,148). 

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