Urea, 1-Methyl

Uron Resins. In the textile industry, the term uron resin usually refers to the mixture of a minor amount of melamine resin and so-called uron, which in turn is predorninantly N,]S -bis(methoxymethyl)uron [7388-44-5] plus 15—25% methylated urea—formaldehyde resins, a by-product. 

Forty years after the initial proposal, Sweet and Fissekis proposed a more detailed pathway involving a carbenium ion species. According to these authors the first step involved an aldol condensation between ethyl acetoacetate (6) and benzaldehyde (5) to deliver the aldol adduct 11. Subsequent dehydration of 11 furnished the key carbenium ion 12 which was in equilibrium with enone 13. Nucleophilic attack of 12 by urea then delivered ureide 14. Intramolecular cyclization produced a hemiaminal which underwent dehydration to afford dihydropyrimidinone 15. These authors demonstrated that the carbenium species was viable through synthesis. After enone 13 was synthesized, it was allowed to react with N-methyl urea to deliver the mono-N-methylated derivative of DHPM 15. 

The Traube synthesis represents but one of the many preparations that have been developed for purines. Transesterification of ethyl carboxamidoacetate with methyl urea affords the diamide... 

Ethyl bromide Acetaldehyde Diethyl malonate Ethanol Methyl urea... 

Preparation of 1-Methyl-5-Allyl-5-( 1-Methyl-2-Pentynyl) Barbituric Acid A solution of 23.8 g of sodium in 360 ml of absolute alcohol was prepared and thereto were added 38.3 g of methyl urea and 96.8 g of diethyl allyl (1-methyl-2-pentynyl) malonate. The mixture was refluxed for about 20 hours, cooled, and the ethanol was removed by distillation in vacuo. The residue was dissolved in about 300 ml of water and the aqueous solution was washed with ether, and the washings were discarded. The aqueous solution was then acidified with acetic acid, and extracted with three 150 ml of portions of ether. 

Chemical Name 1 -(2-Chloroethyl)-1-nltroso-3-[ (2-methyl-4-aminopyrimidin-5-yl)-methyl] -urea... 

C h loro ethyl)-3-[(2-methyl-4-ami no-pyridin-5-yl)methyl] urea Nimustine... 

This suggests that on the surface of the enzyme there is a special arrangement of atoms (belonging to the amino acids of which the protein is constructed) that is just right for attachment of the urea molecule but upon which the methyl urea will not fit. ... 

A simple and efficient method of production of A-methyl ureas, which avoids the use of methyl isocyanate, has been applied to 5//-dibenz[6,/]azepine (5)- 16.ios... 

El-Fantroussi S (2000) Enrichment and molecular characterization of bacterial culture that degrades methoxy-methyl urea herbicides and their aniline derivatives. Appl Environ Microbiol 66 5110-5115. 

Experimental studies showed antitumoral effects of raloxifene in different in vitro preparations and animal models. Raloxifene has been able to inhibit the mitogenic effect induced by estrogens on ZR-75-1 cells, an estrogen responsive human breast cancer cell line (Poulin et al. 1989). In a well-accepted rat model of breast cancer induced by nitroso-methyl urea (NMU) raloxifene significantly suppressed the development of breast tumors and acted synergistically with 9 cis-retinoic acid (Anzano et al. 1996). 

Cotterill [100] studied the effect of ammonium nitrate fertilizer on the electron capture or nitrogen specific gas chromatographic determination of Triazine plus other types of herbicide (Atrazine(2-chloro-4-ethylamino-6-isopropylamino, 1,3,5 triazine), Simazine (2-chloro-4.6 bis ethyl amino 1,3,5 triazine), Linuron (3,4,-chlorophenyl-l-methoxy-l-methyl urea), Metribuzin, Triallate and Phorate) residues in soil. 

Hydroxy phenyl) -1,1 -dimethylurea. see Monuron 3 - (4 - Hydroxy phenyl) -1 -formyl-1 -methyl urea. see Monuron... 

Fig. 1.25. Regulation of alkylation repair in E. coK by methylation of the Ada protein. The effect of methylating agents, such as N-nitroso-N-methyl urea lead to the formation of methyl phospho-triesters (P-Me) of DNA, as well as various base adducts. The Ada protein possesses an N-termi-nal and a C-terminal domain. In one of the first steps of alkylation repair the methyl groups of the phosphotriester is transferred to the Ada protein. The Ada protein is methylated on a Cys residue at its N-terminal domain and thereby transformed into an active transcription activator. In its methylated form the Ada protein binds to the control region of various genes to stimulate their transcription. Among the genes under the control of the Ada protein are its own gene, as well others required for DNA repair (alkB, alkA). After Lindahl et al., 1988.

The reversible and competitive inhibition of calf duodenal adenosine aminohydrolase by relatively low concentrations of urea, methyl urea, and 1,3-dimethyl urea is similar to the urea (104) inhibition of several other enzymes (105). The inhibition appears to involve 1-2 molecules of inhibitor in the inhibition complex (106) determined from log[ (V0/Vi) —... 

Chlorine fluorosulfate, 3969 (Chlorocarbonyl)imidosulfur difluoride, 0317 /V-(Chlorocarbonyloxy)tri methyl urea, 1918... 

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