2-methyl-4,5-trimethylene-isothiazolin-3-one

The addition of a biocide makes a dye substantially lightfast in the presence of this biocide. The biocide may be selected from 1,2-benzisothiazolin-3-one, 2-methyl-4,5-trimethylene-4-isothiazolin-3-one, l-(3-chloroaUyl)-3,5,7-triaza-l-azoniaadamantane, and 6-acet-oxy-2,4-dimethyl-l,3-dioxane (55), cf. Figure 3.39. 

Methyl-4,5-trimethylene-4-isothiazolin-3-one (MTI), 0.01% aqua (analyzing of MTI) (Burden et al. 1994) oc-Naphthylisothiocyanate (CAS 551-06-4), 0.01% acid (synthesis) (Heine and Schulz 1985) Phenoxybenzamine (CAS 63-92-3), 1% aqua (alpha-adrenergic blocking agent) (Mitchell and Maibach... 

The a.m. solution offers a broad spectrum of antibacterial activity which includes Pseudomonades. Fungal growth is controlled by comparatively high concentrations of 2-methyl-4,5-trimethylene-4-isothiazolin-3-one. 

As a liquid product the 5% aqueous formulation of 2-methyl-4,5-trimethylene-4-isothiazolin-3-one offers a number of processing advantages when the product is used for the in-can/in-tank protection of aqueous functional fluids, preferably paints, adhesives and polymer emulsions. In these applications the remarkable water-solubility of the a.i. is a special advantage with an addition rate between 0-05 and 0-2% of the 5% preparation. 

Substances containing an isothiazolone ring, such as 2-methyl-isothiazolin-3-one (MI), benzisothiazolin-3-one (BIT), 2-methyl-4,5-trimethylene-isothiazolin-3-one, also contain activated N-S bonds which may react with nucleophilic cell entities with opening of the isothiazolone ring, thus exerting antimicrobial activity (Miller et ah, 1975). 

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