2-Methyl-4-isothiazolin-3-one

Ethylene glycol monoacetate 5-Chloro-2-methyl-4-isothiazolin-3-one or... 

The combination of 5-chloro-2-methyl-4-isothiazolin-3-one (CIT) and 2-methyl-4-isothiazolin-3-one (MIT) was described by Elsom in 1988 as probably the most cost effective biocide for industrial preservation. This combined product, along with the benzyl derivative (l,2-benzisothiazolin-3-one - BIT) either on their own or combined with other actives comprise the majority of modem wet-state biocides currently in use. 

Because the objective of this work was to assess the benefits of encapsulation, it was decided to opt for one structural class of biocide. The biocides selected for this purpose were based on the isothiazolinone structure. 2 Examples include 2-octyl-4-isothiazolin-3-one (OIT), 4,5-dichloro-2-octyl-4-isothiazolin-3-one (DCOIT), 5-chloro-2-methyl-4-isothiazolin-3-one (CIT) and 2-methyl-4-isothiazolin-3-one (MIT) (Figure 1). 

Another major chemistry often used are isothiazolinones. There are a number of different varieties of this chemistry, probably the most common form used is supplied as a mixture of 5-chloro-2-methyl-4-isothiazolin-3-one and 2-methyl-4-isothiazolin-3-one, (see Figure 5, usually in the ration of 3 1). 

This study was designed to evaluate the performance of commonly used biocides against the performance of a new liquid blend. In order to choose an effective preservative package, the two main criteria the biocide must have, are (i) to be approved by the US Food and Drug Administration (FDA) under sections 21 CFR 176.170 and 21 CFR 176.180 which cover components of paper and paperboard in contact with foods and (ii) to be designated as a safe biocide (low toxicity, non-sensitiser, easy to handle). The three most commonly used products (i) 5-chloro-2-methyl-4-isothiazolin-3-one + 2-methyl-4-isothiazolin-3-one, (ii) 1,5-pentanedial and (iii) l,2-benzisothiazolin-3-one, currently meet the above criteria. The new liquid blend, l,2-dibromo-2,4-dicyanobutane -I- 2-bro-mo-2-nitropropane-l,3-diol was also designed to meet the criteria. 

C4HCI03 3-chloro-2,5-furandione 96-02-6 469.15 40.928 1,2 2529 C4H4CINOS 5-chloro-2-methyl-4-isothiazolin-3-one 26172-55-4 382.85 32.752 1,2... 

Preservatives that are often found in cosmetics include formaldehyde, quaternium-15, imidazolidinyl urea, diazo-lidinyl urea, parabens mix, 5-chloro-2-methyl-4-isothiazo-lin-3-one + 2-methyl-4-isothiazolin-3-one (MCI/MI, Kathon CG), and methyldibromoglutaronitrile (MDBGN, Euxyl K400). Polyhexamethylenebiguanide, a biocide structurally related to hexamidine, is added to cosmetics as a preservative. 

IT based products offer some key advantages as noted in Table 1. For in-can biocide activity, the two IT based products most commonly used are 5-chloro-2-methyl-4-isothiazolin-3-one (CIT) / 2-methyl-4-isothiazolin-3-one (MIT) (CIT/MIT are sold together in a ratio of 3 parts CIT and 1 part MIT) and l,2-benzisothiazolin-3-one (BIT) Table 1 shows the advantages of FD type biocides. In many parts of the world, IT combined with FD biocides are very popular. They offer key advantages such as increased killing power and enhanced stability of CIT/MIT. 

Chem. Descrip. 5-Chloro-2-methyl-4-isothiazolin-3-one, methyl isothiocyanate, and Bronopol (2-bromo-2-nitropropane-1,3-diol)... 

Chem. Descrip. 5-Chloro-2-methyl-4-isothiazolin-3-one/methyl isothiocyanate aq. formulation, sodium nitrate-stabilized Uses Biocide for wet-state systems, paints/coatings, inks, and formulations incompat. with bivalent metals, e.g., urethane/styrene acrylic emulsions and other polymer emulsions Features Bivalent metal-free Acticide OTW [Thor UK]... 

Chloromethylbenzene. See Monochlorotoluene (ChloromethyO benzene. See Benzyl chloride (ChloromethyO ethylene oxide. See Epichlorohydrin Chloromethylisothiazolinone 5-Chloro-2-methyl-4-isothiazolin-3-one 5-Chloro-2-methyl-2H-isothiazol-3-one. SeeMethylchlorolsothlazolinone Chloromethyloxirane 2-(Chloromethyl) oxirane. See Epichlorohydrin (Chloromethyl) oxirane, 4,4 -(1-methylethylidene) bisphenol copolymer. 

Methyl-4-isothiazolin-3-one 2-Methyl-3(2H)-isothiazolone. See Meth-ylisothiazolinone... 

Chloromethylisothiazolinone 5-Chloro-2-methyl-4-isothiazolin-3-one 5-Chloro-2-methyl-2H-isothiazol-3-one. See Methylchloroisothiazolinone Chloromethylmercury. See Methyl mercury (II) chloride... 

Methylisothiazolinone CAS 2682-20-4 EINECS/ELINCS 220-239-6 Synonyms 3(2H)-lsothiazolone, 2-methyl- 2-Methyl-4-isothiazolin-3-one 2-Methyl-3(2H)-isothiazolone... 

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