Methyl sulfone PCBs

Letcher RJ, RJ Norstrom, DCG Muir (1998) Biotransformation versus bioaccumulation sources of methyl sulfone PCB and 4,4 -DDE metabolites in polar bear food chain. Environ Sci Technol 32 1656-1661. 

Bergman A, RJ Norstrom, K Haraguchi, H Kuroki, P Belaud (1994) PCB and DDE methyl sulfones in mammals from Canada and Sweden. Environ Toxicol Chem 13 121-128. 

Bergman, A., M. Athanasiadou, S. Bergek, K. Haraguchi, S. Jensen, and E.K. Wehler. 1992a. PCB and PCB methyl sulfones in mink treated with PCB and various PCB fractions. Ambio 21 570-576. 

Y1 Mouse adrenocortical tumor Adrenocortical cell Methyl sulfone metabolites of DDT and PCBs Inhibition of corticosterone synthesis by competitive inhibition of cytochrome P450... 

Larsson, C. Norstrom, K. Athanansiadis, I. Bignert, A. Konig, W.A. Bergman, A, Enantiomeric specificity of methylsulfonyl-PCBs and distribution of bis(4-chlorophenyl) sulfone, PCB, and DDE methyl sulfones in grey seal tissues Environ. ScL TechnoL 2004, 38, 4950 955. 

Larsson, C. Ellerichmann, T. Hiihnerfuss, H. Bergman, A., Chiral PCB methyl sulfones in rat tissues after exposure to technical PCBs Environ. ScL Technol 2002, 36, 2833-2838. 

Ellerichmann, T. Bergman, A. Franke, S. Hiihnerfuss, H. Jakobsson, E. Konig, W.A. Larsson, C., Gas chromatographic enantiomer separations of chiral PCB methyl sulfons and identification of selectively retained enantiomers in human liver Fresenius Environ. Bull. 1998, 7, 244-257. 

GC-coupled mass spectrometry with electron ionization (EI-MS) or with electron capture, negative ionization (ECNI-MS), and GC with electron capture detection (ECD) have been the major techniques for the analysis of aryl methyl sulfone fractions isolated from tissue (Sect. 5.1). GC/ECD detection and identification of MeS02-PCBs relies on a comparison of GC retention times relative to authentic standards, which is dependent on the absence of co-eluting interfe-rents. GC/MS techniques have provided important structural information for MeS02-PCBs, especially in the absence of authentic standards. 

MeS02-PCBs are initially co-extracted from tissue with other OHS and lipids. Lipid-rich tissues such as adipose, liver and lung have been homogenized with dichloromethane (DCM) and n-hexane/2-propanol (3 2) to co-extract lipid and OHS [95,117, 118]. Tissues have also been homogenized with acetone/n-hexane and extracted with n-hexane/diethyl ether or methyl tert-butyl ether (MTBE) [119]. Mammalian adipose and liver and whole fish have been dehydrated with sodium sulfate prior to extraction with n-hexane/DCM (1 1) [11, 96]. Human liver and feces have been extracted with benzene and refluxing by Soxhlet [120], Formic acid has been added to milk samples in preparation for further cleanup [16], After extraction, OHS and aryl methyl sulfones have been separated from lipids by various techniques. Lipid destructive strategies include saponifi-... 

Brandt, I, Bergman A. 1987. PCB methyl sulfones and related compounds Identification of target cells and tissues in different species. Chemosphere 16 1671-1676. 

Haraguchi K, Athanasiadou M, Bergman A, et al. 1992. PCB and PCB methyl sulfones in selected groups of seals from Swedish waters. Ambio 21 546-549. 

Methyl sulfones are ultimate mammalian metabolites of PCBs produced by a series of reactions involving arene oxides and glutathione conjugates and have been synthesized to enable their conclusive identification and quantification (Bergman and Wach-meister 1978 Haraguchi et al. 1987). This is discussed further in Section 7.5.2. 

Polychlorinated biphenyls (PCBs) - methyl sulfones Bromocyclane (Bromodan)... 

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