Methyl phenyl acetate

A related agent, g1 icetanile sodium (42), is made b / a variant of this process. Methyl phenyl acetate is reacted with chlorosulfonic acid to give 38, which itself readily reacts with aminopyrimidine derivative 39 to give sulfonamide Saponification to acid 4 is followed by conversion to the acid chloride and amide formation with 5-chloro-2-methoxyaniline to complete the synthesis of the hypoglycemic agent glicetanile (42). ... 

Methyl Phenyl-acetate. — Phenyl-acetic acid can be prepared by... 

It is very similar in odour and use to methyl phenyl-acetate. 

Scheme 22 Anodic conversion of aryl alkyl ketones to methyl phenyl acetates.

In June 1992, we reasoned that the preparation of methyl tropate via the reaction of formaldehyde with methyl phenyl acetate may provide a low-cost intermediate capable of being reduced to PPD. The preparation of ethyl tropate via this route was already published.5 However, the German workers found that formation of ethyl 2-phenylacrylate was substantial. In addition, no ongoing reduction of methyl tropate to PPD was described (Scheme 2). 

The acid chloride was prepared from (+)-a-methoxy-a-(trif1uoro-methyl)phenyl acetic acid which was used as obtained from Aldrich Chemical Company, Inc. 

Example 4.29. 77te Wolff rearrangement of diazoacetophenone to methyl phenyl-acetate. 

C9H10N2S 4-thiocyano-N,N-dimethyl aniline 7152-80-9 371.35 31.674 1,2 16682 C9H10O2 3-methyl phenyl acetate 122-46-3 485.15 42.459 1,2... 

Japanese cedar (Cryptomeria japonka) Anaj lyptus subjiisciatus Methyl Phenyl Acetate (R)-3-hydroxy-2-hexanone, (R)-3-hydroxy-2-octanone [222]... 

CAS 122-46-3 EINECS/ELINCS 204-546-2 Synonyms Acetic acid, 3-methyl phenyl ester Acetic acid m-tolyl ester m-Acetoxytoluene Acetyl metacresol Cresatin m-Cresol acetate m-Cresol acetic acid ester Metacresol acetate 3-Methyl phenyl acetate m-Methylphenyl acetate... 

Synonyms Acetic acid-4-methylphenyl ester 4-Acetoxytoluene p-Acetoxytoluene Acetyl p-cresol p-Cresol acetate p-Cresylic acetate 4-Methylbenzoic acid methyl ester 4-Methyl phenyl acetate p-Methylphenyl acetate Paracresyl acetate p-Tolyl acetate p-Tolyl ethanoate Classification Aromatic ester Empirical C9H10O2 Formula CH3CO2C6H4CH3 Properties Colorless liq., anise sweet fragrant odor sol. in fixed oils, propylene glycol misc. with alcohol, ether insol. in water, glycerin m.w. 150.18 dens. 1.047 b.p. 210-211 C dec. 360 C flash pt. 90 C ref. index 1.5010 Toxicology LD50 (oral, rat) 1900 mg/kg, (skin, rabbit) 2100 mg/kg mod. toxic by ing. and skin contact irritant TSCA listed Precaution Combustible Hazardous Decomp. Prods. Heated to decomp.. 

The effect of making X more electron withdrawing is to stabilize the complexes in the corners B and D relative to A and C. As a result the transition state is shifted towards corner A ("Hammond effect") and toward corner B ("Thornton effect") as shown in Fig. lb. The net result of the two effects is to shift the transition state in the direction of more proton transfer and a should increase. This is again borne out by the results a similar trend in a was found for the phenoxide ion departure from substituted benzaldehyde methyl phenyl acetals (13). 

C21H34O2 (4-methyl-phenyl)-acetic acid dodecyl ester 102456-03-1... 

Obtained by Fries rearrangement of 2,4-dichloro-5-methyl-phenyl acetate with aluminium chloride at 135° (21%) [2496],... 

COCH3 - Preparation by Fries rearrangement of 2-bromo-4-methyl-phenyl acetate,... 

Preparation by Ries rearranganent of 4-bromo-3-methyl-phenyl acetate with aluminium chloride without solvent at 165-180° [2515,2518], (80%) [2518]. 

Also obtained by Fries rearrangement of 2-ethyl-4-methyl-phenyl acetate [2596,2907], (40%) [2907] or 2-ethyl-5-methylphenyl acetate (41%) [2596] with aluminium chloride at 130-140°. 

Preparation by Fries rearrangement of 2-ethyl-5-methyl-phenyl acetate by heating with aluminium chloride (30%) [2907]. b.p.,2 137-138° [2233], b.p. 270° [2907],... 

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