Methyl 2-hydroxyacetate

Preparative Methods methyl 2-hydroxyacetate is converted to methyl 2-benzyloxyacetate (1, NaH 2, BnBr, DMF, 0°C to rt, 80%). The acetate is then treated with LiOH H20 (1.25 equiv) in THF-H2O at rt to give 2-benzyloxyacetic acid (99%). The acid is converted to the corresponding acid chloride (ox-alyl chloride (2.7 equiv, 60 °C, 1.5 h), which is treated with thiazolidine-2-thione in the presence of triethylamine in dichlo-romethane to give the title reagent 1 (81% from the acid). Handling, Storage, and Precautions use in a fume hood. 

Af-Methylguanidine acetic acid, c277 4-Methylhexahydrophthalic anhydride, ml 96 Methyl hydroxyacetate, m259... 

Sonawane et al. (Sonawane et al., 1994) described a practical and efficient synthesis of fenoprofen using commercially available m-phenoxybenzaldehyde as the starting material. The key step in the synthesis is the transformation of the a-hydroxyacetal (i) into its chlorosulfonyl ester in situ and its concomitant rearrangement to the methyl ester (ii) in high yields. The required a-hydroxyacetal (i) can be readily prepared from m-methoxybenzaldehyde by the routine sequence of reactions Grignard reaction with ethyl bromide or chloride, oxidation and finally a-chlorination with CuCI2-LiCI/DMF. 

A mixture of linear and angular chromenes (70) and (71) resulted from the reaction of 1,3 -dihydroxyacridone with the hydroxyacetal. Methylation of the angular isomer gave acronycine, which shows broad-spectrum antitumour activity. 

Pyrolysis of the ethylene acetal of bicyclo[4.2.0]octa-4,7-diene-2,3-dione yields a-(2-hydroxyphenyl)-y-butyrolactonc 11 a mechanism involving a phenyl ketene acetal is proposed. Tartrate reacts with methanediol (formaldehyde hydrate) in alkaline solution to give an acetal-type species (9) 12 the formation constant was measured as ca 0.15 by H-NMR. Hydroxyacetal (10a) exists mainly in a boat-chair conformation (boat cycloheptanol ling), whereas the methyl derivative (10b) is chair-boat,13 as shown by 1 H-NMR, supported by molecular mechanics calculations. 

Phenyl-(a-thienyl)hydroxyacetic acid 2-Diethylaminoethyl chloride Methyl bromide... 

The producing of phenyl-(a-thienyl)hydroxyacetate of 2-diethylmethylaminoethyl bromide may be carried out by methylation of phenyl-(a-thienyl)hydroxyacetate of 2-diethylaminoethyl hydrochloride with methylbromide. 

B.07 2.B.08 2.B.09 2.B.10 Arsenic trichloride 2,2-Diphenyl-2-hydroxyacetic acid 3-Quinuclidinol 2-iV,iV-Dialkylaminoethyl chloride iV-Ethyl-iV-methyl-2-aminoethyl chloride... 

Hydroxyacetic aldehyde, hydroxypropanone, furfural and 5-methyl-furfural are pyrolysis products of carbohydrates (JA), but the ab-... 

Optically active ( , )-l-methyl-2-butenyl hydroxyacetate (4) rearranges at room temperature upon trapping of the initially formed dianion with chlorotrimethylsilane via its Z-configurated silyl ketene intermediate 5 with high chiral transmission490. 

EsEs-1 (Figure 5) and EsEs-2 (Figure 6) - dimers formed by two molecules of the methyl ester of a-hydroxyacetic acid... 

The diazoester of hydroxyacetic add methyl ester 87 was prepared via the chloro-formate 86 using diphosgene as chloroformylating agent [47]. 

Monochloroacetic Acid Glycolic Acid Hydroxyacetic Acid Methyl Acetate Peracetic Acid Acetylene Tetrabromide 1,1/2,2-Tetrabromoethane Isobutyric Acid 2-Methylpropanoic Acid... 

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