3-Methyl group, oxidation

Metabolic stereoinversion R to S) C-2 hydro-xylation terminal methyl group oxidation... 

Trinitrobenzene is present in crude TNT manufactured by mixed acid nitration and results from methyl group oxidation followed by decarboxylation." In fact, a convenient method for the synthesis of 1,3,5-trinitrobenzene involves oxidation of 2,4,6-trinitrotoluene with a solution of sodium dichromate in sulfuric acid, followed by decarboxylation of the resulting 2,4,6-trinitrobenzoic acid in boiling water." 1,3,5-Trinitrobenzene is prepared from 2,4,6-trinitro-m-xylene by a similar route." 2,4,6-Trinitroanisole can be prepared from the... 

Ring and aryl methyl group oxidation were the initial toluene-degradation routes speculated on for the nitrate-reducing enrichment obtained by Kuhn etal. (1988) and the metabolically diverse iron-reducing bacterium Geobacter metallireducens (Lovley Lonergan, 1990). The speculation was consistent with the fact that both of these cultures could metabolize the appropriate suite of putative intermediates. However, conclusive evidence as to which pathway was actually involved was not obtained. 

Moles of CO2/IOO moles of acetaldehyde methyl group oxidized to by-products. Calculated by difference. CO2 = 100—(CH4 + CH3—O— + HCHO + HCO2—). 

Bianchini F, Hall J, Donato F, Cadet J (1996) Monitoring urinary excretion of 5-hydroxymethyluracil for assessment of oxidative DNA damage and repair. Biomarkers 1 178-184 Bienvenu C, Wagner JR, Cadet J (1996) Photosensitized oxidation of 5-methyl-2 -deoxycytidine by 2-methyl-1,4-naphthoquinone characterization of 5-(hydroperoxymethyl)-2 -deoxycytidine and stable methyl group oxidation products. J Am Chem Soc 118 11406-11411 Bothe E, Behrens G, Schulte-Frohlinde D (1977) Mechanism of the first order decay of 2-hydroxypro-pyl-2-peroxyl radicals and of O2 formation in aqueous solution. Z Naturforsch 32b 886-889 Bothe E, Deeble DJ, Lemaire DGE, Rashid R, Schuchmann MN, Schuchmann H-P, Schulte-Frohlinde D, Steenken S, von Sonntag C (1990) Pulse-radiolytic studies on the reactions of S04 with uracil derivatives. Radiat Phys Chem 36 149-154... 

Experiments with C- and H-acetate showed that the methyl group of acetate is the major precursor of methane and the carboxyl-carbon is oxidized to CO2, providing electrons for reduction of the methyl-carbon to CH4 [7,231,232]. However, Krzyeki et al. [233] showed that 14% of the methane produced by whole cells of an acetate-adapted strain of M. barkeri originated from the carboxyl-carbon, and an equivalent amount of CO2 came from methyl-group oxidation the reduction of carboxyl-carbon to methane has also been observed in extracts [7,234]. 

The second group of methanogenic substrates have in common that CH4 is formed by the reduction of a methyl group with electrons derived either from methyl-group oxidation, from molecular hydrogen or from the oxidation of an enzyme-bound carbon monoxide. 

It is probable that the reaction proceeds in two steps first, the p-toluidine has the methyl group oxidized to the aldehyde group yielding p-amino benzaldehyde second, this aldehyde then reacts with aniline just as benzaldehyde does with benzene in the synthesis of tri-phenyl methane (p. 735). 

The photooxidation of these compounds can be contrasted to the thermal oxidation of 5 at 175°C (Table III). Three major products were isolated, all arising from methyl group oxidation (10). One molecule of starting material disappears per mole of oxygen consumed and compound 6, having no methyl groups, is stable at 175°C. It is therefore clear that the mechanisms of thermal and photooxidations are different. 

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