Methyl ethyl ketone, as solvent

Thin-layer chromatography on alumina,271 silica gel,139,271>272 cellulose,262,272 Avicel,250,262 and polyamide273 thin layers has extended considerably the applications of chromatography to the separation and purification of imidazoles. Polyamide layers are useful especially for the separation of imidazoles and their 1-methyl derivatives and (using methyl ethyl ketone as solvent) allows separation of the more polar co mpounds su ch as 1,3 -dimethylimidazolium iodide.2 7 3 Imidazolines have also been separated by thin-layer chromatography.274... 

PdCl2(PPh3)2 catalyzed homogeneous carbonylation of l-(4 -isobutylphenyl) ethanol, in which some of the isomeric linear acid, 4- -Bu-C6H4CH2CH2C02H, is also formed typical yields are 92% of ibuprofen and 6% of the linear acid (see also Section 4.3.1). The carbonylation is performed at 50 bar, 130°C, in an acidic aqueous medium containing chloride ions, a ketone (such as methyl ethyl ketone) as solvent, and at least 10% of water [V. Elango et al., US Patent 4 981 995 (1991)]. A convenient ratio of substrate palladium catalyst is 10 1. A 3.5kt/a plant in Bishop, Texas has been operated by BHC since 1992. The palladium catalyst can be precipitated from the organic phase of the carbonylation reaction and re-used without further treatment. 

To achieve good compatibility with functionalized acrylic and epoxy resins a bis cyclic urea with n=3> and R=-(CH2)7-(see Scheme I) was synthesized. Acrylic- and epoxypolymer solutions were prepared using 15% by weight of the bis cyclic urea (based on the dry polymer) and methyl ethyl ketone as solvent. Films cast from these solutions on steel sheets were clear, and had a thickness of 0.4 mil. 

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