3’-methyl-4-dimethylaminoazobenzen

METHYLDIMETHOXYSII NE see MJE900 3 -METHYL-4-DIMETHYLAMINOAZOBENZEN (CZECH) see DUH600... 

Miyamoto, K., Wakusawa, S., Nomura, M., Sanae, F., Sakai, R., Sudo, K., Ohtaki, Y., Takeda, S., Fujii, Y. Effects of Gomisin A on hepato-carcinogenesis by 3 -methyl-4-dimethylaminoazobenzene in rats. Japan... 

Hirano T, Higashi K, Sakai A et al. (2000) Analyses of oxidative DNA damage and its repair activity in the livers of 3 -methyl-4-dimethylaminoazobenzene-treated rodents. Jpn J Cancer Res 91 681-5... 

Makiura S, Aoe H, Sugihara S, et al. 1974. Inhibitory effect of polychlorinated biphenyls on liver tumorigenesis in rats treated with 3 -methyl-4-dimethylaminoazobenzene, N-2-fluorenylacetamide, and diethylnitrosamine. J Natl Cancer Inst 53 1253-1257. 

Y Ohtani, M nomura, T Hida, K Miyamoto, M Kanitani, T Aizawa, M Aburada. Inhibition by gomisin A, a lignan compound, of hepatocarcinogenesis by 3 -methyl-4-dimethylaminoazobenzene in rat. Biol Pharm Bull 17 808-814,1994. 

Patel, N. T., Yoshida, M., and Holoubek, V., In vitro incorporation of 3 -methyl-4-dimethylaminoazobenzene into liver nuclei and release of RNA from the nuclei, Cancer Res., 41, 743,1981. 

When various spices were screened for their ability to potentiate the typical carcinogen-detoxifying enzyme GST in Swiss mice, cumin seeds (Cuminum cyminum Linn.), basil leaves (Ocimum sanctum Linn.), and turmeric increased the enzyme activity by more than 78% in the stomach, liver, and esophagus. GSH levels were also significantly elevated in all three organs by these plant products. These spices also significantly suppressed the chromosome aberrations caused by BaP in mouse bone-marrow cells. In a subsequent study, cumin seeds and basil leaves significantly decreased the incidence of both BaP-induced squamous cell carcinomas in the stomach of Swiss mice and 3 -methyl-4-dimethylaminoazobenzene-induced hepatomas in Wistar rats. ... 

Hawtrey A.O., Nourse, L.D. 1964. The effect of 3 -methyl-4-dimethylaminoazobenzene on protein synthesis and DNA-dependent RNA-polymerase activity in rat-liver nuclei. Biochim. Biophys. Acta 80 530-532. 

All glycolytic enzymes are increased in amount during carcinogenesis (37, 346). Glucokinase is increased to 570% of its control value in the liver of animals exposed to the carcinogen 3 -methyl-4-dimethylaminoazobenzene (12). 

Methyl yellow, p-dimethylaminoazobenzene, benzeneazodimethylaniline (indicator) dissolve 0.1 g in 200 mL alcohol pH range red 2.9-4.0 yellow. The color change from yellow to orange can be perceived somewhat more sharply than the change of methyl orange from orange to rose, so that methyl yellow seems to deserve preference in many cases. See also under methyl orange. 

Methyl Red (4-dimethylaminoazobenzene-2 -carboxylic acid) [493-52-7] M 269.3, m 181-182 , Cl 13020, pK j 2.30, pK2 4.82. The acid is extracted with boiling toluene using a Soxhlel apparatus. The crystals which separated on slow cooling to room temperature are filtered off, washed with a little toluene and recrysld from glacial acetic acid, benzene or toluene followed by pyridine/waler. Alternatively, dissolved in aq 5% NaHC03 soln, and ppted from hot soln by dropwise addition of aq HCl. Repealed until the extinction coefficients did not increase. 

Suitably substituted azo compounds constitute an important class of dyes—the azo dyes. Some derivatives such as /j-dimethylaminoazobenzene- p -sulfonic acid Na-salt (trivial name methyl orange) are used as pH-indicators. 

Methyl yellow indicator 0.1% (w/v) p-dimethylaminoazobenzene in absolute ethanol... 

Methyl Yellow (p-Dimethylaminoazobenzene) Yellow crystals, melting between 114° and 117°. Insoluble in water soluble in alcohol, in benzene, in chloroform, in ether, in dilute mineral acids, and in oils. Transition interval from pH 2.9 (red) to 4.0 (yellow). 

As a general statement, isomerizations occur much slower (around lOOtimes and more) in the film than in solution. It was already observed for azo compounds by Kamogawa et in the case of copolymers of 4-vinyl-4 -dimethylaminoazobenzene (I) with styrene and of 4-acryloylaminomethylaminoazobenzene (II) with styrene, butyl acrylate and methyl methacrylate. 

Abbreviations conform to Tarr s nomenclature F, formic acid A, acetic acid fA, trifluoroacetic acid KNm, dimethylformamide mSO, methylsulfoxide MOH, methanol EOH, ethanol MCN, acetonitrile M5KN, N-methyl-pyrrolidone 6N, pyridine N, ammonia ENm, dimethylethylamine M6N, N-methylpiperidine M6NO, N-methylmorpholine E6NO, N-ethylmorpholine ENip, diisopropylethylamine eN, triethylamine fmK, hexafluoroacetone (hydrate) cit, citric acid W, water NaA, sodium acetate eN+, tetraethylammonium MNT, methylthiocarbamyl NT, phenylthiocarbamyl MNGS, methylisothiocyanate ONCS, phenylisothiocyanate NPN-TNdab, N-aminopropyl-N -p-dimethylaminoazobenzene thiourea. 

Methyldopa, 3-(3,4-dihydroxyphenyl)-2-methyl-L-alanine Methyl Yellow, /)-dimethylaminoazobenzene Mixed solvents... 

Synonyms p-Dimethylaminoazobenzene (DAB) N,N-Dimethyl-4-(phenylazo) benzenamine Methyl yellow C.I. solvent yellow 2 C.I. 11020... 

Figure 1 Induction of hepatic aminoazo dye N-demethylase and reductase activities. Rats (50 g) were injected once with 1 mg of 3-methylcholanthrene (3-MC). N-Demethylase activity was determined in fortified liver homogenates by measuring the metabolism of 3-methyl-4-monomethylaminoazobenzene to 3-methyl-4-aminoazobenzene (3-methyl-AB). Reductase activity was determined by measuring the reduction of the azo linkage of 4-dimethylaminoazobenzene (DAB). Demethylase activity is expressed as fig of 3-methyl-AB formed per 50 mg of liver per 30 min. Reductase activity is expressed as fig of DAB reduced per 30 mg of liver per 30 min. Each point is the average of the activities for two or three rats. Taken from Ref. (4).

The azo indicators, such as dimethylaminoazobenzene (butter yellow, methyl or dimethyl yellow), are usually but slightly soluble in water and therefore unsuited for the quantitative determination of pH. If several drops of a 0.1% alcoholic... 

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