5-Methyl-dibenzo azepine

Methyl-dibenzo[b,fl azepine (4.1 g), N-diethylaminoborane (1.7 g) and freshly distilled toluene (150 cc) are introduced into a 500 cc three-neck flask equipped with a dropping funnel and a condenser, and protected against moisture by a calcium chloride guard tube. The solution Is heated under reflux (110°C) for 22 hours under a nitrogen atmosphere and then cooled. A 2N aqueous sodium hydroxide solution (33 cc) is then run in followed by an... 

N aqueous methylchloramine solution (190 cc), the addition of which takes 9 minutes. The mixture is stirred for 1 hour and then decanted. The organic layer is washed with water until it has a pH of 6 and is then extracted with 2 N hydrochloric acid (5 times 50 cc), dried over sodium sulfate, filtered and evaporated. Recrystallization of the residue from petroleum ether yields some unconverted 5-methyl-dibenzo[b,f] azepine (2.17 g). 

Methyl-dibenzo[b,f]azepine Methylamine Sodium hypochlorite... 

An almost complete resolution was attained between unlabeled and di-, tri-, or tetradeuterated drugs active on the central nervous system -l,2,3,4,10,14b-hexahydro-2-methyl- dibenzo [c,/]py-razino[l,2-fl]azepine (mianserin [VII]) and 1,3,4, 10,14b-hexahydro-2,7-dimethy l-2H-dibenzo [c,f -py-razino[l,2fl]oxazepine (Org GC 94 [VIII]). [3,3,-4,4- H4]Org GC 94 was chromatographed on p-Porasil column and n-hexane-2-propanol (90 10, v/v) to which a solution of 4% ethanol and 0.1%... 

The aqueous acid solution is rendered alkaline by adding 2 N sodium hydroxide solution. After extracting with diethyl ether (3 times 100 cc), drying the extracts over potassium carbonate, treating them with decolorizing charcoal, filtering and evaporating the ether, a yellowish oil (0.9 g), identified as 5-methyl-10-methylamino-10,11 -dihydro-dibenzo[b,f] azepine, is obtained in a yield of 37.5%. 

Bis(2-nitrophenyl)amine (la) is reduced by zinc/ sodium hydroxide to a mixture of 117/-dibenzo[r, /][l,2,5 triazcpine (2a) and the V-oxidc 3a.325 The reaction of Ar-methylbis(2-ni-trophenyl)amine with lithium aluminum hydride provides 11-methyl-1 l//-dibenzo[c,/][l,2,5]tri-azepine (2b).153... 

Stereochemistry also plays an important role in the recently disclosed 3,4-dihydropyrimidinethione analogs [32]. Racemic dihydropyrimidine derivative (32) is reported to inhibit activation by the TRPA1 agonist HH-dibenzo[fc,e]azepine-10-carboxylic acid methyl ester (16) with an IC50 value of 128 nM for human TRPA1 in HEK293 cells. 

H3C.n J H desipramine [3-(10,11-Dihydro-dibenzo[b,f]azepin-5-yl)-propyl]-methyl-amine, C18H22N2, MW 266.39, [50-47-5] diabetic neuropathy (12.5-150 mg/day for 15 weeks) Max etal., 1992 Sindrup et al., 1990a... 

The 2.0 g of previously obtained crude product is suspended in 20 ml of N,N-dimethylformamide, and 710.0 mg of sodium methylate in 10 ml of methanol are added. After maintaining for 30 min at room temperature, 2.5 ml of methyl iodide are added, and mixture is allowed to stand for 24 h after which the mixture is poured into water, the product filtered off, dried and crystallized from ethanol, to give 5-methyl-10-acetamino-5,6-dihydro-llH-dibenzo[b,e] azepine-6,ll-dione, melting point 199°-201°C. 

Fourteen seven-membered ring compounds have been tritium-labelled by AcT, AdT or HTI methods165 including ( )3,3,5-trimethylhexahydroazepine—162, 2-oxohex-amethyleneimine (caprolactam)—163, l-aza-2-methoxy-l-cycloheptene—164, 1,4-dia-zacycloheptane (homopiperazine)—165, l,8-diazabicyclo-[5.4.0]undec-7-ene—166, 5H-dibenzo[6j/]azepine (iminostilbene)—167, 8-chloro-l 1-(4-methyl-l-piperazinyl)5//-... 

SYNS 2-CHLORO-l l-(4-xMETHYL-l -PIPERAZINYL)-DIBENZO(b,f)(l,4)OXAZEPINE 2-CHLORO-ll-(4-METHYL-l-PIPERAZINYL)-DIBENZO(b,f)(l,4)0X0-AZEPINE CL-62362 CL-71563 CLOXAZEPINE DIBENZOAZEPINE HF3170 LOXAPINE LW3170 OXILAPINE S-805 SUM 3170... 

The major adducts formed when phenanthridine is allowed to react with dimethyl acetylenedicarboxylate have been reformulated. - An initial Michael-type reaction gives the zwitterion (206) and succeeding reactions depend on the nature of the solvent. Adduct (207) is formed in anhydrous methanol by the addition of a proton and methoxide ion, while in benzene nucleophilic attack on the carbonyl group of a second ester molecule and subsequent cyclization provides 208. Alternatively, reaction at the triple bond of a second molecule of ester followed by ring closure of the new zwitterion gives 209. Other products related to 207 arise if the methanol contains water. 6-Methylphenanthridine with dimethyl acetylenedicarboxylate in benzene gives a mixture of the azepine (210) and tetramethyl 9a-methyl-9aA-dibenzo[a,c]quinolizine-6,7,8,9-tetracarboxylate. The... 

Cl9H16N2O3, 5-Diacetylamino-3,4-diphenylisoxazole, 406, 335 C19H1eBrN302, 2-(4 Methyl-2 morpholino-1H-5 imidazolylmethylidene)-4-bromo-1,2-dihydro-1-oxonaphthalene, 406, 336 C19H20N2O, 2-(N-Morpholinomethyl)-5H-dibenzo[b,f]azepine, 456, 411 C19H20N2O2, 2,3 11,12-Dibenzo-1,13-dioxa-5,9-diaza-2,4,9,11-cyclo-pentadecatetraene, 456, 412... 

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