Methyl chloroform chemical structure

A mixture of 8.0 g (4.2 mmol) methoxynoria, 8.2 g (60 mmol) K2CO3, and 0.064 g (0.2 mmol) tetrabutylammonium bromide in 95 ml NMP (1-methyl-2-pyrrolidone) is stirred at 60°C for 3 h. After that, a solution of 4.3 g (1.5 mmol) BMA (2-bromoacetyloxy-2-methyladamantane) in 5 ml NMP is added slowly to the resultant mixture, poured into chloroform, and washed with 0.1 M oxalic acid aqueous solution and water. The organic layer is dried over MgS04, and the solution is concentrated by rotary evaporator. The concentrated solution is added to methanol to obtain the white solid. The resulting precipitate is collected by vacuum filtration and dried at 60°C in vacuo for 12 hr. Thus, adamantylester of noria is finally obtained. The chemical structure of noria profecfed by adamantane is shown in Figure 3.18. 

CHLORINATED HYDROCARBON An Organic compound having chlorine atoms in its chemical structure. Trichloroethylene, methyl chloroform, and methylene chloride are chlorinated hydrocarbons. 

In 1883, the hydroxy structure 82 was assigned to indoxyl on the basis of chemical evidence. More recently, however, the infrared spectra of 1-acetyl- and 1-methyl-indoxyl measured in chloroform indicated that the oxo form 83 (R = Ac, Me) greatly predominates, " ... 

Applying mild extraction methods to the mycelium of an ergo-cristine producing Claviceps purpurea strain, an unstable peptide alkaloid of a new type was recently detected (17). Its physical data and chemical transformations contributed to the elucidation of its structure. The fast methanolysis of the new alkaloid led to the well-known N-lysergyl-L-valine methyl ester (18) and L-phenylalanine-D-proline lactam. An amino acid analysis showed the presence of one mole each of valine, phenylalanine, and proline. Thus the new alkaloid has been characterized as iV-[AT-(d-lysergyl)-L-valyl]-L-phenylalanyl-D-proline lactam (18 C35H39N504 mp 235° [a]D +5° in chloroform). 

Nowadays research on the structure of compounds relies on the interpretation of spectral information whereas older work was mainly dependent on the preparation of derivatives and on degradative experiments. The parent compound (9,10-anthraquinone) could be identified by zinc dust distillation or zinc dust fusion. The position of the hydroxyl groups could be established by the use of selective reagents. Hydroxyl groups at the 2-position are readily methylated with diazomethane. Chelated 1-hydroxyl groups are resistant to most chemicals but are affected by methyl iodide/silver oxide/chloroform or methyl sulphate/potassium carbonate/acetone mixtures [1],... 

Complete determination of the structure of these compounds required evaluation of both chemical and physical data. The observed chemical reactivity favors the indicated cyclic structure. Oxaselenin 18 is transformed into the corresponding furan and diphenylselenide upon treatment with methyl iodide (Equation 16). The alternative betaine structure 63 would be expected to afford the methoxyselenonium salt under these conditions (Equation 17). Refluxing 18 in chloroform, or allowing the chloroform solution of 18 to stand at room temperature, also led to the formation of the selenide and corresponding furan (Equation 18). The structure of 18 was confirmed ultimately by X-ray crystallography (see Section 9.15.3.1). 

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