Methyl-2-aminoacetate

Palladium-catalysed asymmetrie allylations of various carbonyl compounds have been studied by Hiroi et al. using various types of chiral sulfonamides derived from a-amino acids. In particular, the chiral bidentate phosphinyl sulfonamide derived from (5)-proline and depicted in Scheme 1.63 was employed in the presence of palladium to eatalyse the allylation of methyl aminoacetate diphenyl ketimine with allyl aeetate, leading to the eorresponding (7 )-product with a moderate enantioseleetivity of 62% ee. This ligand was also applied to the allylation of a series of other nueleophiles, as shown in Seheme 1.63, providing the eorresponding allylated produets in moderate enantioseleetivities. 

The first example of a stable geminal enediol derivative of a carboxylic acid, isolated as its platinum(II) complex, has been reported.324 Treatment of [Pt(OH2)2(en)]2+ with /V,/V-bis(phos-phonomethyl)aminoacetic acid yields zwitterionic [Pt(bpmaa)(en)] (bpmaaH = 7V,7V-bis(phosphono-methyl)aminoacetic add), which upon crystallization from water (pH 1) affords the corresponding enol tautomer (130), as determined by X-ray crystallography and IR spectroscopy. 

Sodium methoxide. See Sodium methylate Sodium 4-methoxybenzaldehyde bisulfite. See Sodium anisaldehyde bisulfite Sodium 4-(methoxycarbonyl) phenolate. See Sodium methylparaben Sodium methyl aminoacetate. See Sodium sarcosinate... 

In this chapter, the results of study of extraction properties of two new liquid extraction agents—methyl phosphorylated derivative natural amino acids— N-methyl aminoacetic acid—sarcosine (1) and -alanine (2) in processes of liqtrid extraction of a mrmber of metals iorrs (Table 11.1) are provided. The potential eoordination centers in used reagents are marked by asterisk. 

The desired long spacer necessary to allow multiple branch construction, was obtained with commercial tetra(ethylene glycol) which was readily modified into aminoacetal 21 in five steps (Scheme 8). Using 21 as an amine source, poly(amidoamine) (PAMAM) dendrons were prepared according to published protocol using reiterative cycles of methyl acrylate and ethylenediamine reactions. The terminal amines of each generation (G = 1, G = 2 and G = 3, 22a-c) were obtained quantitatively from each of the half generation methyl ester precursors. 

Alkylation of trifluoro- and trichloroacetamides with a-bromoacetic esters has been utilized for the synthesis of a wide range of a-aminoacetic acids [11-13] (Table 5.13). Hydrolysis of the intermediate a-trihaloacetamidoacetic esters with methanolic potassium hydroxide converts the methyl and ethyl esters directly into the amino carboxylic acids. /-Butyl a-aminoacetates are more stable, but they are hydrolysed under phase-transfer catalytic conditions (see Chapter 9.2). Reaction of the trihaloacetamides with 1,4-dibromobutane and 1,5-dibromopentane and subsequent hydrolysis provides a simple route to pyrrolidine-2-carboxylic acid (75%) and piperidine-2-carboxylic acid (58%) [11, 12],... 

The condensation of cyanoguanidine and aminoacetal (or its methyl-homologue) yields the expected diethylacetal of biguanidoacetaldehyde this is cyclisable to 2-guanidinoimidazole (or its 1-methyl-homologue) (VIII) by means of mineral acids (576). 

Methimazole Methimazole, l-methyl-2-imidazolthiol (25.2.5), is synthesized by reacting aminoacetic aldehyde diethylacetal with methylisothiocyanate and snbseqnent hydrolysis of the acetal group of the resulting disubstituted urea derivative 25.2.4 by a solution of sulfuric acid, during which a simultaneous cyclization reaction takes place, forming the imidazole ring of the desired methimazole [15,16]. 

The S-methyl compound (140) (R = Me), when treated with aminoacetal 152, yielded imidazodiazocine 153 (R = H). If, in addition, various electrophiles are added, such as aroyl isothiocyanates and aroyl chlorides, N-substituted compounds 153 (R = CONHC6H3R2 (R2 = Cl, Me) 3,4,5-(OMe)3C6H2CO, and 5-N02-2-furyl] are obatined [761JC(B)773]. Reaction of isoureas 113 (R = Me, Et) or isothioureas 140 (R = Me, Et) with hydrazine gave 106 (R = NH2). The latter compound was condensed with pyruvate or 2-ketophenylacetate esters to afford diazocino-l,2,4-triazinones 154 (R = Me, Ph) (72LA112). 

The term amino acid might mean any molecule containing both an amino group and any type of acid group however, the term is almost always used to refer to an a-amino carboxylic acid. The simplest a-amino acid is aminoacetic acid, called glycine. Other common amino acids have side chains (symbolized by R) substituted on the a carbon atom. For example, alanine is the amino acid with a methyl side chain. 

Aluminum Identification Test, 753 Aluminum Magnesium Silicate, 41 Aluminum Potassium Sulfate, 21 Aluminum Sodium Sulfate, 21 Aluminum Sulfate, 22 Ambrette Seed Liquid, 23 Ambrette Seed Oil, 23, 596 Aminoacetic Acid, 186 A-[4-[[(2-Amino-l,4-dihydro-4-oxo-6-pteridinyl)methyl] amino] benzoyl] -l-glutamic Acid, 157 3 - Amino-7-dimethylamino-2-methylphenazine Chloride, 861 L-2-Aminoglutaramic Acid, 175 L-2-Amino-5-guanidinovaleric Acid, 32, (S3)5... 

Diazoacetic Acid, Methyl Ester or Methyldiozo acetate (called Diazoessigsaure-methylester in Ger), N2CH.CO2.CH3 mw 100.08, N 27.99% It-yel expl liq, bp 31° at 12mm Hg discillacion, even under reduced pressure, is extremely dangerous, since heat causes the cotnpd to detonate violently d 1,158 at 25° Hq 1.4515 11 31,4676 at 20.6° was prepd by diazotization of aminoacetic acid methyl ester with HNO2 (Refs 1, 2 8 3) ... 

Using two moles of aminoacetic acid to each mole of carbon disulfide causes the reaction to follow a different path (S55). N,N -bis(carboxy-methyl) thiourea (CLXXXIV) is formed which, on refluxing with hydrochloric acid, undergoes ring closure to the 1- carboxymethyl)imida-zolidin-5-one-2-thione (CLXXXV). 

Heating the aminoacetal (2.1) with ethanolic hydrogen chloride produces a quinoline [2612], but sulphuric acid causes the cyclization to follow another course (see Chapter 3, Section II. 1). n-Aminoaldehydes are cyclized by heating with a reactive methylene-containing ketone, ester or nitrile but in the reaction with the pyrazole aldehyde (2.2), yields seem to depend greatly on the nature of the A -substituent for example, when R = R = CN, the product is obtained in either 3.6% or 83% yields according to whether R is methyl or phenyl [2798]. The chemistry of a-cyanothioacetamide (2.4), which is used in the conversion of 2-aminobenzaldehyde (2.3) to 2-aminoquinoline-3-thiocarboxamide [2926], has been reviewed [3331]. 

In cases of ethyl AT-methyl-A,-(3-nitro-2-pyridyl)aminoacetates 5 with a tertiary amino nitrogen as the corresponding sarcosine ester, treatment with bases such as sodium ethoxide or potassium carbonate in ethanol produces 4-alkyl-l-hydroxypyrido[2,3-b]pyrazine-2,3(l/f,4//)-diones 6 as the principal products in low yield.8 9... 

The Raney nickel catalyzed hydrogenation of ethyl (3-nitro-4-pyridyl)aminoacetate (3a) in ethanol yields 57% of l,2-dihydropyrido[3,4-h]pyrazin-3(4//)-one (4a). From methyl 2-[(3-nitro-4-pyridyl)amino]propanoate (3b), the corresponding 2-methyl derivative 4b is obtained in 19% yield.97... 

Sodium N-methyl-N-(l-oxotetradecyl) aminoacetate. See Sodium myristoyl sarcosinate... 

The melting point of the hydrochloric acid salts of 2-alkoxyethyl aminoacetic acid decreased in the order Cn, Cb, Ch in the same series [95]. Addition of an aminoethyl group increased the melting point of the compounds. The introduction of a methyl group at the N of the long-chain alkoxy-substituted glycines lowered their melting points. 

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