2-aminoethyl groups

Cyanoethyl groups can be conveniently reduced to 2-aminoethyl groups using Raney nickel-hydrogen to give 2-aminoethyl-substituted ortho esters [149] (Eq. 49). 

The f-butylcalix[4]arene with two 2-aminoethyl groups at the distal positions of the narrow rim was easily reacted with sugar derived thioisocyanates to give the corresponding thioureas containing two D-glucose 35a, D-mannose 35b, D galactose 35c, or D-lactose 35d moieties.72... 

Unsymmetrical disulfides of MEA of type II were found active in mice vs. 1000 r, the most promising being zwltter-ions Good protection was given where X was C02 or SO3 and where the 2-aminoethyl group was replaced by 2-pyrldylmethyl. 

Alkylation by aziridines is of interest because it can introduce the 2-aminoethyl group which is found in many biologically active indoles. Zinc triflate was found to be the best catalyst for effecting enantiospecific alkylation of indoles by l-(Cbz)aziridine-2-carboxylate esters <89TL4073>. Aziridine (31) was used to stereospecifically introduce an a-methyltryptophan side-chain using BF3 as the catalyst (Equation (80)) <90CPB564>. 

Sosnovskikh VY, Vorontsov II, Kutsenko VA, Yatluk YG (2000) Unexpected isomerization in the series of fluorine-conteuning 2,3-dihydro-l//-l, 4-diazepines with a 2-aminoethyl group at one of the nitrogen atoms. Mendeleev Commun 10 56-58... 

Aminoethylethanolamine (AEEA) physical properties of, 2 1241 specifications, 2 32t Aminoethyl group, ion-exchange group used in protein purification, 3 830t Aminoethylpiperazine... 

Aminoethyl groups in cyclic compounds in which anhydro-ring formation is not possible can be converted in good yield into hydroxy-ethyl groups by the action of nitrous acid (see p. 57). 

An enormous variety of cationic azo structures have appeared in the patent literature and many of these have achieved commercial status. As previously described, they can be divided conveniently into two types depending on the location of the charge. Pendant charges can be introduced (e.g. 32) by the incorporation of a suitable aminoethyl group in a disperse type dye (69BRP1147546). 

Uoto, K. Akenoshita, H. Yoshino, T. Hirota, Y Anido, S. Mitsui, I. Tersawa, H. Soga, T. Synthesis and evaluation of water-soluble non-produrg analogues of docetaxel bearing jec-Aminoethyl group at the C-10 position. Chem. Pharm. Bull., 1998, 46(5) 770-776. 

Figure 7-14A). The base peak at m/z 305 might arise from the neutral loss of a 2-vinylamino-ethanol. The product ions formed by the neutral loss of 73 (2-methyleneamino-ethanol) and 44 (Ethenol) Da from the precursor ion of m/z 392 were also consistent with the proposed structure (Figure 7-15A). The production spectra of impurities D and E were similar in two ways. Both have a base peak at m/z 88 which was produced when an A-(2-hydroxyethyl) aminoethyl group was cleaved from the molecule. Both produce a less intense product ion that was 61 Da less than the precursor ion (Figure 7-15 m/z 278 in D, and m/z 263 in E). This 61-Da loss was found to be the loss of a 2-aminoethanol neutral. Further studies suggested that impurities D and E are photo-decomposition products of DuP 941[87]. Based on the LC/MS/MS data,... 

This group is similar to the 2-(A/-formyl-A/-methyl)aminoethyl group and is cleaved similarly from a phosphate in CH3CN with a i/2 ====" 50min. 

Several procedures required for the preparation of porphyrins with labile side chains have already been referred to above or in the earlier article, for example, the conversion of acetoxyethyl or aminoethyl groups (introduced at the pyrrole stage) into vinyl groups. The preparation of porphyrin 3-keto esters has now been improved by the use of imidazolides (rather than acid chlorides) in condensations with magnesium methyl hydrogen malonate. The porphyrin acyl imidazolides have also been converted into acrylic esters by the sequence porCo-imidazole - -CH2OH — CHO - CH = CHC02Me. Alternatively the porphyrin ketoesters may be reduced with borohydride to hydroxyesters and dehydrated to acrylic esters. ... 

The very low number of polymer chains per particle achieved in a microemulsion polymerization (one on average) was taken advantage of to produce Mannich polyacrylamides (i.e., substituted with tertiary aminoethyl groups) without significant interpolymer crosslinking as is the case for those prepared in invo emulsions. The Mannich acrylamide polymers, in the form of inverse microemul-sions, were found to provide superior dewatering characteristics compared to those obtained conventionally [57]. 

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