5- Methoxycarbonyl-2-methoxycarbonylamino

N-Methoxycarbonyl-isothioCyanat (aus Kaliumisothiocyanat und Kohlensaure-chlorid-me-thylester) liefert mit o-Diamino-arenetl in Gegenwart von Dicyclohexyl-carbodiimid (DCC) 2-Methoxycarbonylamino-benzimidazole z. B. 5-(4-Fluor-benzoyl)-2-methoxycarbonylamino-benzimidazol (55% Schmp. > 300°)3OS a 2S8 ... 

Amino-4-methoxycarbonylamino-l,3-thiazol-Hydrochlorid (R1 = H)463 Eine Mischung von 1,52 g (0,01 mol) N-Methoxycarbonyl-ehlor-acetamid, 0,76 g (0,01 mol) Thioharnstoff und 40 mol Aeeton wird 5,5 h unter RuckfluB erhitzt. Nach dem Abkiihlen wird der Niederschlag abgesaugt und mit Aeeton gewaschen Ausbeute 2 g (95%) Schmp. 175° (Zers.). 

Methoxycarbonylamino-3-athoxycarbonylamino-2-(4-carboxy-butyl)-tetrahydro-durch katal. Hydrierung von 4- Mcthoxycarbonyl-amino-3-athoxycarbonylamino-2-(4-carb-oxy-butyl)-thiophen mit Pd/C 364 2-Methoxycarbonyl-2,5-dihydro- 639 2-Methoxy methyl- 362 2-Methyl- 55... 

The first recorded example of a 2,1,4-benzothiadiazine appears to be the 3-phenylamino-l//-derivative (49) which was obtained as a yellow crystalline solid by oxidative ring-closure of N- 2-aminophenyl)-V -phenylthiourea (48) with aqueous ferric chloride (Equation (6)) <29JICI81>. In a related manner, reduction of the V-(2-nitroaryl)-V -(methoxycarbonyl)thioureas (50) with sodium dithionite <7iGEP2l0846i, 88IJC(B)672> or with sodium hydrosulfide in DMF <72GEP2215733> affords the 3-methoxycarbonylamino-l//-2,l,4-benzothiadiazines (51) (Equation (7)), the 5-oxides of which (see Section 6.15.4.2) are useful anthelmintics (see Section 6.15.9). 

In a similar way, starting from N-methoxycarbonyl-5-cyano-l, 2-dihydropyri-dine (437), peracetylated 5-methoxycarbonylamino-5-deoxy-DL-xy/opentopiper-idinose (438) was obtained. ... 

Synonyms BCM 2-Benzimidazolecarbamic acid, methyl ester IH-Ben-zimidazole-2-yl methyl carbamate N-2-(Benzimidazolyl) carbamate 1 H-Benzimidazol-2-ylcarbamic acid methyl ester BMC Carbendazol MBC 2-(Methoxycarbonylamino) benzimidazol 2-(Methoxycarbonyl-amino) benzimidazole Methyl 2-benzimidazolecarbamate Methyl ben-zimidazole-2-yl carbamate Methyl benzimidazol-2-yl carbamate 2-(Methyloxycarbonylamino) benzimidazole Empirical C,H,NA... 

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