First recorded example

It is interesting to note that Saunders, Stacey, Wild and Wilding6 have brought about the reaction between triethyl phosphite and bromofluoroethane (II), giving diethyl 2-fluoro-ethylphosphonate (HI), thus providing the first recorded example of the 2-fluoroalkyl group attached to phosphorus ... 

The first recorded examples of fully self-contained completely metallic cartridges were the pinfire cartridges of the early 1850s. These consisted of a thin copper cartridge case with a striker pin projecting radially from the base end (brass came into general use in the 1870s and replaced copper as the case... 

The synthesis20 of a derivative of l-azabicyclo[3.2.0]heptane (12, n = 2) by this method represents the first recorded example of this ring system. The reactions are generally carried out without... 

The first recorded example of a 2,1,4-benzothiadiazine appears to be the 3-phenylamino-l//-derivative (49) which was obtained as a yellow crystalline solid by oxidative ring-closure of N- 2-aminophenyl)-V -phenylthiourea (48) with aqueous ferric chloride (Equation (6)) <29JICI81>. In a related manner, reduction of the V-(2-nitroaryl)-V -(methoxycarbonyl)thioureas (50) with sodium dithionite <7iGEP2l0846i, 88IJC(B)672> or with sodium hydrosulfide in DMF <72GEP2215733> affords the 3-methoxycarbonylamino-l//-2,l,4-benzothiadiazines (51) (Equation (7)), the 5-oxides of which (see Section 6.15.4.2) are useful anthelmintics (see Section 6.15.9). 

The maytolins are an interesting instance of new sesquiterpenes from the Celastraceae characterized by the presence of a tetrahydro-oxepine nucleus. It would seem that these new types of skeleton are only biosynthesized by species of the Mortonia genus, which consists of just four species, endemic to Mexico and the southern United States. The structures proposed for mortonins A and B, Fig. (4), are the first recorded examples of a natural product in which ring B of the eudesmane skeleton undergoes oxidative cleavage to the the y-lactone [126]. 

The first recorded example where the shifts of the different nuclei in a molecule were separated by chemical shift was ethanol (CH3CH2OH). 

Acid-catalysed decomposition of the diazo-ketone (330) results in cyclization to the spiro-ketone (331) in the first recorded example of Ar,-4 participation. ... 

Application of nitrous acid deamination to the naturally occurring chitosamine 45) (2-amino-2-deoxy-D-glucose) provided Fischer and Tie-mann 46) with the first recorded example of a hydrofuran anhydro sugar. The sirupy product, chitose, could be oxidized to give, successively, an... 

The first recorded example of thermomechanical coupling, as explained in the Les-... 

The first recorded example of the ,Z-isomerization of a CN double bond was that of oximes by Hantzsch in Zurich, who reported in 1890 that ,Z-isomerization took place when the tolylphenyl ketone oxime or a-anisylphenyl ketone oxime was irradiated. Subsequent to this study, Ciamician and Silber at Bologna reported that when E-o- and p-nitrobenzaldehyde oximes, as suspensions in benzene, were exposed to sunlight, they were converted to the corresponding Z-nitrobenzaldehyde oximes. This report was confirmed and extended to O-methyloximes by Brady and Dunn in London (Scheme 1). Stoermer also found a similar photochemical ,Z-photoisomerization with certain ketoximes." ... 

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