2-METHOXYCARBONYLAMINO BENZIMIDAZOLE

Tab. 13 2-Methoxycarbonylamino-benzimidazole durch Cyclisierung von 2-Nitro-anilincn mit Thio-kohlensaure-methoxycarbonylamid-methoxycarbonylimid-rnethyiester nach Reduktion in situ...

N-Methoxycarbonyl-isothioCyanat (aus Kaliumisothiocyanat und Kohlensaure-chlorid-me-thylester) liefert mit o-Diamino-arenetl in Gegenwart von Dicyclohexyl-carbodiimid (DCC) 2-Methoxycarbonylamino-benzimidazole z. B. 5-(4-Fluor-benzoyl)-2-methoxycarbonylamino-benzimidazol (55% Schmp. > 300°)3OS a 2S8 ... 

Synonyms BCM 2-Benzimidazolecarbamic acid, methyl ester IH-Ben-zimidazole-2-yl methyl carbamate N-2-(Benzimidazolyl) carbamate 1 H-Benzimidazol-2-ylcarbamic acid methyl ester BMC Carbendazol MBC 2-(Methoxycarbonylamino) benzimidazol 2-(Methoxycarbonyl-amino) benzimidazole Methyl 2-benzimidazolecarbamate Methyl ben-zimidazole-2-yl carbamate Methyl benzimidazol-2-yl carbamate 2-(Methyloxycarbonylamino) benzimidazole Empirical C,H,NA... 

These studies indicated that replacement of the methoxycarbonylamino group at 2-position of benzimidazoles by acylamino or urea pharmacophores may help to retain the biological activity, although they are weaker than the benzimidazole-2-car-bamates. Thus, it may be concluded that the presence of a methoxycarbonylamino function at 2-position of a 5(6)-substituted benzimidazole is usually essential for optimal anthelmintic activity. 

Benzimidazolecarbamic acid, 5-(phenylthio)-, methyl ester Carbamic acid, (5-(phenylthio)-1H-benzimidazol-2-yl)-, methyl ester CCRIS 7309 EINECS 256-145-7 Fenbendazol Fenbendazole Fenbendazolum Hoe 881 v 2-(Methoxycarbonylamino)-5-(phenylthio)benzimidazole Methyl 5-(phenylthio)-2-benzimidazolecarbamate Meth-yl (5-(phenylthio)-1 H-benzimidazol-2-yl)carbamate Pa-naour Phenbendasol. Anthelmintic (nematodes). Crystals mpa 233° (dec) insoluble in H2O, organic solvents, freely soluble in DMSO. HoechstAG. 

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