Methoxy methylsulfonate

Methylesculetol-6,7-dinicotinate (32) is useful as an antiinflammatory and vasodilator oflow toxicity (101). The synthesis of asarone [5555-15-1] (2,4,5-trimethoxy-l-propenylbenzene), which is used as a tranquilizer, has been patented (102). It occurs in calamus root, Acorns calamus L.y and is a chemosterilant for insects (103). 6,7-Dihydroxycoumarin-4-methylsulfonic acid and its salts are useful in the treatment of capillary permeability and fragility and for protecting oxidizable metabolites and drugs against biooxidation (104). Certain chromones derived from hydroxyhydroquinone, eg (33), and its salts, esters, and amides are valuable in the prophylactic treatment of asthma (105) (see Antiasthmatic agents). 2-Methoxy-6-multiprenyl-l,4-benzoquinones are intermediates in the microbiological synthesis of coenzyme Q compounds (106). 

Pd complexed with 2-pyridyldiphenylphosphine (or its 6-methylpyridyl derivative) and weakly coordinating counter ions, such as methylsulfonate, are employed as catalyst [84, 85]. After the coordination of methanol and CO the migration of the methoxy group takes place to form the palladium carbomethoxy species. Then the coordination of propyne takes place. The steric bulk of the pyridyl group, and in particular of the 6-methylpyridyl group, induces the con-... 

Imino-diphcnyl- 1127.1262 Isocyanat-phenyl- 895 lsopi openyloxysulfon- -sulfinsaurc 1040 lsopropyloxy-bis-[phenylsulfonyl]- 1218 Isopropyloxy-phenyl- 1080 lsothioeyanalo-diphenyl- 77 lxolhiocyanalo-triphenyl- 177 Mercaplo- 1014, 1054,1378 Mercapto-phenyl- 1015 Methoxy-bis-[phenylsulfonyl]- 1218 Methoxy-diphenyl- 1217 Methoxy-phenyl- 581, 1080 4-Methoxy-phenyl- -sulfonsaure-ester 1182 Methylamino-diphenyl- 1446, 1447 Methylmercapto-methylsulfon- 1076 Methylmercapto-phcnyl- 1378 4-Methyl-phenyl- -sulfonsa ure-ester 1182 4-Nitro-phenyl- -sulfonsaure-ester 1182 Nitroso-phenyl- 731 Nitro- -sulfonylchlorid 168 Phenyl- 232... 

In Equation 149, the chlorosulfonation occurs, as expected, in the / ara-position relative to the electron-donating (-f I) methylene moiety and simultaneously the three chlorine atoms attached to the silicon atom are sequentially substituted by chlorosulfonate and methoxy groups to give the methylsulfonate 470. In this context, it is well known ° that chlorosilanes react with chlorosulfonic acid to yield the corresponding chlorosulfonate esters, as occurs in the first stage of the conversion shown (Equation 149). 

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