7-methoxy-2-methyl-4-oxo

Methoxy-2-methyl-4-phenyl-l-beDzoteIluriiiiiini Trifluoromethanesulfonatc2 1 ml] of a solution of 1.57 g (10 mmol) of bromobenzene in 5 ml] of dry tetrahydrofuran is added to a slurry of 0.41 g (17 mmol) of magnesium turnings in 3 ml] of dry tetrahydrofuran. A 20 mg crystal of iodine is added and, when the iodine color has faded, the rest of the bromobenzene solution is added dropwise to the magnesium slurry. The mixture is heated under reflux for 1 h, a solution of l.Og (3.3 mmol) of 7-methoxy-2-methyl-4-oxo-477-l-benzotellurin in 5 ml] of dry tetrahydrofuran is added, the resultant mixture is heated under reflux for 1 h, and then cooled to 0°. A saturated aqueous solution of ammonium chloride is added dropwise, the resultant mixture is diluted with 100 ml] of water, and then extracted with three 25 ml] portions of dichloromcthane. 

H-l-BenzotelIurin 7-Methoxy-2-methyl-4-oxo- E12b, 823 (ArTe - CR = CH - COOH/... 

Methoxy-2-methyl-4-oxo-3,4-dihydropyrido 2,3-cf pyrimidiiie-6-carbonitrile (38) Typical Procedure 53... 

Dioxo-l,4,7,10-tetrahydro-l,10-phenanthroline (72) with dimethyl sulfate gives l,4-dihydro-7-methoxy-l-methyl-4-oxo- 1,10-phenanthroline (73) rather than a quaternary salt, steric hindrance presumably preventing alkylation of both nitrogens.203 A related alkylation has also been reported.295 1,2,3,4-Tetrahydro-1,10-phenanthrolines similarly form 1-alkyl derivatives rather than 10-alkyl quaternary salts with alkyl halides.38 The rate of methylation of 1,10-phenanthroline with methyl iodide in dimethyl sulfoxide has been studied,296 and the polaro-graphic reduction of 1 -methyl- 1,10-phenanthrolinium iodide was reported.286... 

Reduction of 3-benzyl-8-chloro-4-oxo-4//-pyrido[l,2- ]pyrimidine-2-carboxylate <2004W004/064741> and 2-methyl-4-oxo-4//-pyrido[l,2-tf]pyrimidine-3-carboxylate <2003T4123> with DIBAL-H afforded 2- and 3-formyl derivatives, respectively. Reduction of /V-(4-fluorobenzyl)-3-hydroxy-8-[methoxy(methyl)amino]-4-oxo-6,7,8,9-tetra-hydro-4//-pyrido[l,2- ]pyrimidine-2-carboxamide with Zn-dust in aqueous AcOH afforded the 8-methylamino derivative, which was acylated with AcOH in the presence of Hiinig s base, HOBt, and l-(3-dimethylaminopro-pyl)-3-ethylcarbodiimide-HCl <2004W004/058756>. 3-(Perhydropyrido[l,2- ]pyrimidin-2-yl)propylamine was obtained by catalytic hydrogenation of 2-(perhydropyrido[l,2- ]pyrimidin-2-yl)propionitrile over a Pt02 catalyst <2003FRP1275647>. 

Aziridin l-tert.-Butyl-2-oxo-3-phenyl- E16b, 7 (aus Br — CR2 — CO — NHR), 10 (aus R2CH-CO-NR-Cl) 5H-1-Benzazepin 7-Methoxy-2-methyl-3,4-dihydro- E14b, 234 (Tetralin 4 HN3)... 

Pyrethrin II, CjjHjjO, 3-(3-methoxy-2-methyl.3-oxo-l-fmpenyl)-2,2 dimethyicyclopropanecarboxyiic acid 2-methyl 4-penten-1 -vl ester. ehrysan-tlumamdicarboxylic acid monomethyl ester pyrethrolone ester. R = COOCHj. Viscous liquid. Oxidizes rapidly and becomes inactive in air. bPsatr 192-193 - njj 1.5355. [a]tf +14.7 (isooctane-ether), uv max (95% ethanol) 229 an (e 45,850). Practically insol in water sol in ale, petr ether dess sol than pyrethrin I), kerosene, carbon tetrachloride, ethyl -me dichloride, nitromethane. LDm orally in rats 1.2 g/kg. 

N-[2-Hydroxy-2-(4-hydroxy-3,5,5-trimethyl-6-oxo-l-cyclohexen-l-yl)-l- methoxymethyl)ethyl -7-methoxy-9-methyl-4-hexadecenamide, 9CI [67488-05-5]... 

Dimethoxy-6 5-methoxy-6-methyl-4-oxo-4H-pyran-2-y[)-2 phenyl-4 l-l-benzopyran-4-one, 9CI [151590-48-6]... 

Dimethoxy-6-(5-methoxy-6-methyl-4-oxo-4//-pyran-2-yl)-2-phenyl-4//-1 -benzopyran-... 

Amino-7-methoxy-2-methoxycarbonyl-3-phenyl-5,8-quinoxalinequinone 6-Amino-7-methoxy-l-methyl-2-oxo-3-phenyl-1,2-dihydro-5,8-quinoxalinequinone 3-Amino-6-methoxy-8-nitro-2-quinoxalinecarbo-nitrile 1,4-dioxide... 

Heating diethyl (l-isoquinolylamino)methylenemalonates in diphenyl ether gave ethyl 4-oxo-4//-pyrimido[2,l-a]isoquinoline-3-carboxylates (97) (78USP4127720). Cyclization of diethyl[(4-amino-l-isoquinolyl)amino] methylenemalonate in a mixture of acetic anhydride and pyridine in methylene chloride at ambient temperature afforded ethyl 7-acetylamino-4-oxo-4//-pyrimido[2,l-a]isoquinoline-3-carboxylate [84JAP(K)84/172472]. The 7-nitro derivative was prepared similarly. Cyclization of diethyl [(7-methoxy-3-methyl-l-isoquinolyl)amino]methylenemalonate in polyphos-phoric acid at 130°C for 6 h gave 10-methoxy-6-methyl-4//-pyrimido[2,l-a]isoquinolin-4-one in 29% yield [94IJC(B)795]. 

Methyl (9i ,12S)-12-[(Benzyloxycarbonyl)(methyl)ammo]-4-methoxy-10-methyl-ll-oxo-2-oxa-10-aza-tricyclo[12.2.2.13 7]nonadeca-l(16),3(19),4,6,14,17-hexaene-9-carboxylate (19) 1C ... 

Hortiamine, which can lower blood pressure, is a red alkaloid and the major hypotensive component of the bark of the Brazilian plant Hortia arborea (Rutaceae). Chemically, it is 10-methoxy-14-methyl-5-oxo-5,7,8,14-tetrahydroindolo[2, 3 3,4]pyrido[2,l-6]quinazoline.43 When boiled with moist benzene it forms a yellow product, hydrated as shown in 44, and Amaxfalls from 411 nm to 375 nm. The anhydrous form is regenerated on gentle drying.71... 

Ethyl-6-methoxy-4-oxo-1,4-dihydro-1, 5-naphthyridine-3-carboxylic acid 1 -Ethyl-7-methoxy-4-oxo-1,4-dihydro-1, 5-naphthyridine-3-carboxylic acid Ethyl 5-methyl-4,8-dioxo-1,4,5,8-tetrahydro-1,5-naphthyridine-3-carboxylate 3-Ethyl- 1-methyl- l,5-naphthyridin-2(l/7)-one Ethyl 7-methyl-4-oxo-1,4-dihydro-1, 5-naphthyridine-3-carboxylate 1 -Ethyl-7-methyl-4-oxo-1,4-dihydro-1, 5-naphthyridine-3-carboxylic acid 1 -Ethyl-7-methylthio-4-oxo-1,4-dihydro-1, 5-naphthyridine-3-carboxylic acid... 

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