Methadone substance

The term opioid refers to any exogenous substance that acts as an agonist at any of several receptors. Opioid antagonists are drugs that bind to a receptor but produce no actions. The poppy plant, Papaver somniferum, from which opium is obtained, is grown in many areas of the world. Morphine constitutes 10% of opium, and codeine can be obtained direcdy from opium. Semisynthetic opioids such as heroin and oxycodone are obtained directly or indirectly from morphine. There are other distinct chemical classes of drugs with opioid actions, including the methadones. 

Jaffe JH Drug dependence opioids, nonnarcotics, nicotine (tobacco), and caffeine, in Comprehensive Textbook of Psychiatry, 5th Edition, Vol 1. Edited by Kaplan HI, Sadock BJ. Baltimore, Williams c Wilkins, 1989, pp 642-686 Jaffe J, Knapp CM, Ciraulo DA Opiates clinical aspects, in Substance Abuse A Comprehensive Textbook. Edited by Lowinson JH, Ruiz P, Millman RB, et al. New York, Lippincott Williams and Wilkins, 2004, pp 158—165 Jarvis MA, Schnoll SH Methadone use dming pregnancy. NIDA Res Monogr 149 58— 77, 1995... 

A dramatically different pattern is found in surveys of drug abuse treatment facilities. Substance abuse treatment centers have reported that more than 20% of patients use benzodiazepines weekly or more frequently, with 30%— 90% of opioid abusers reporting illicit use (Iguchi et al. 1993 Stitzer et al 1981). Methadone clinics reported that high proportions ofurine samples are positive for benzodiazepines (Darke et al. 2003 Dinwiddle et al. 1996 Ross and Darke 2000 Seivewright 2001 Strain et al. 1991 Williams et al. 1996). The reasons for the high rates of benzodiazepine use in opioid addicts include self-medication of insomnia, anxiety, and withdrawal symptoms, as well as attempts to boost the euphoric effects of opioids. 

Rawson RA, Huber A, McCann M, et al A comparison of contingency management and cognitive-behavioral approaches during methadone maintenance treatment for cocaine dependence. Arch Gen Psychiatry 59 817—824, 2002 Rohsenow DJ, Monti PM, Martin RA, et al Motivational enhancement and coping skills training for cocaine abusers effect on substance use outcomes. Addiction... 

The stereospecificity of antigen-antibody reactions has gained its due recognition more than half-a-century ago. However, an intensive and extensive stereospecificity radioimmunoassay procedures have been adequately applied to a number of pharmaceutical substances since mid-seventies, for instance atropine, propranolol, methadone-to name a few. 

Kolar, A.F., Brown, B.S., Haertzen, C.A. and Michaelson, B.S. (1994) Children of substance abusers the life experiences of children of opiate addicts in methadone maintenance. American Journal of Drugand Alcohol Abuse 20, 2, 159-171. 

Undoubtedly leads to more relapsing into substance abuse and associated problems than methadone maintenance... 

Banbery J, Wolff K Raistrick D (2000). Dihydrocodeine a useful tool in the detoxification of methadone-maintained patients. Journal of Substance Abuse Treatment, 19, 301-5... 

Covi L, Hess JM, Kreiter NA Haertzen CA (1995). Effects of combined fluoxetine and counselling in the outpatient treatment of cocaine abusers. American Journal of Drug Alcohol Abuse, 21, 327-44 Craig RJ, Olson R Shalton G (1990). Improvement in psychological functioning among drug abusers inpatient treatment compared to outpatient methadone maintenance. Journal of Substance Abuse Treatment, 1, 11-19... 

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