Sensorineural hearing loss methadone

A 35-year old Caucasian man with AIDS and multiple opportunistic infections, including Mycobacterium kansasii and Mycobacterium avium complex (MAC) disease developed moderate to severe primary sensorineural hearing loss after 4—5 months of therapy with oral azithromycin 500 mg/day. Other medications included ethambutol, isoniazid, rifabutin, ciprofloxacin, co-trimoxazole, fluconazole, zidovudine (later switched to stavudine), lamivudine, indinavir, methadone, mod-ified-release oral morphine, pseudoephedrine, diphenhydramine, megestrol acetate, trazodone, sorbitol, salbutamol by metered-dose inhaler and nebulizer, ipratropium, and oral morphine solution as needed. Significant improvement of the hearing impairment was documented 3 weeks after drug withdrawal. 

Sudden sensorineural hearing loss following methadone overdose was described in two adults (a husband and wife), who presented on the same night [38 ]. Both had ingested unknown large quantities of methadone. The hearing loss reversed completely within 24 hours. 

Christenson BJ, Marjala ARP, Foss M. Two cases of sudden sensorineural hearing loss after methadone overdose. Ann Phar-macother 2010 44(1) 207-10. 

Sensory systems Acute bilateral sensorineural hearing loss followed methadone overdose (75 mg) in an opioid-naiVe individual there was gradual improvement in hearing over 10 days [89 ]. 

EAR, NOSE, THROAT A case report of a 31-year-old male who developed sudden sensorineural hearing loss after a methadone-induced stupor which did not resolve after withdrawal of methadone suggesting that hearing loss from methadone use may be permanent [48 ]. 

Saifan C, Glass D, Barakat I, El-Sayegh S. Methadone induced sensorineural hearing loss. Case Rep Med 2013 2013 242730. 

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