Metarrhizium anisopliae

Interestingly, similar habitat association was recently discovered in an insect pathogen, Metarrhizium anisopliae, where forest and field populations were found differing in UV and cold tolerance and no host specificity was found (Bidochka et al., 2001). 

Bidochka MJ, Kamp AM, Lavender TM, Dekoning J, De Cross JNA. Habitat association in two genetic groups of the insect-pathogenic fungus Metarrhizium anisopliae Uncovering cryptic species Appl Environ Microbiol 67 335-1342, 2001. 

Isoindoles are not known to occur as natural products again, there is a marked contrast with the indoles. However, the cytochalasins, a group of mold metabolites having a marked effect on cell division, contain a highly substituted isoindoline nucleus (3). Cytochalasins A and B (4 and 5) have been obtained from Helminthosporium dematioideum,1 cytochalasins C and D (6 and 7) from Metarrhizium anisopliae,8 and the cytochalasins 8 and 9 from the fungus Phomopsis paspalli found on an Indian millet.9... 

Destnixins. Cyclic depsipeptides from Metarrhizium anisopliae and Oospora destructor (Hyphomycetes) with insecticidal activity. Destruxin 8 is a host-specific phytotoxin from Altemaria brassicae. The D. are optically active, mostly crystalline compounds. For the most important D., see the table. 

There is no commercial use for the individual substances. The D. have supporting effects in the parasit-ization of insects by Metarrhizium anisopliae. For biosynthesis and incorporation experiments of, e.g., C labelled acetate, see Lit., for detection, see Ut.. D. B reversibly suppresses the expression of hepatitis B viral surface antigen (HBsAg) gene in human hepatoma cells and may have potential for development as a specific anti-HBV drug. ... 

IjCytochalasans Cytochalasin C (75,165,18/ ,21 R)-21 -Acetoxy-7,18-dihydroxy-16,18-dimethyl-10-phenyl-[ 11 Jcytochalasa-5(6), 13( ), 19( )-triene-1,17-dione C30H37NO6 5 Metarrhizium anisopliae Aldridge and Turner (1969a)... 

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