Phomopsis paspalli

Isoindoles are not known to occur as natural products again, there is a marked contrast with the indoles. However, the cytochalasins, a group of mold metabolites having a marked effect on cell division, contain a highly substituted isoindoline nucleus (3). Cytochalasins A and B (4 and 5) have been obtained from Helminthosporium dematioideum,1 cytochalasins C and D (6 and 7) from Metarrhizium anisopliae,8 and the cytochalasins 8 and 9 from the fungus Phomopsis paspalli found on an Indian millet.9... 

An important class of potent mammalian toxins is associated with the pathogen P. paspalli and some other unidentified Phomopsis fungi. The toxic effects of P. paspalli were most likely first reported in the ancient text Arthasastra (300 B.C.) which describes the consumption of kodo millet grains as "a poison for tigers" Kodo millet (Paspalum scrobiculatum) is a crop grain cultivated in India, particularly... 

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