Metamizole sodium

C18H17N3O 83-17-0) see Metamizole sodium l-(benzylidenamino)-2,4-imidazolidinedione (CK1H9N3O2 2827-57-8) see Azimilide hydrochloride... 

Ci4HijIN,02 92254-87-0) see Azimilide hydrochloride 4-benzylidenemethylammonio-2,3-dimethyl-l-phenyl-5-A -pyrazolone methyl sulfate (C20H23N3O5S) see Metamizole sodium... 

Metamizole sodium Methamizole sodium, l-phenyl-2,3-dimethyl-4-methylaminopyra-zolone-5-A -sodium methansulfonate (3.2.16), is synthesized in a multi-stage synthesis from acetoacetic ester and phenylhydrazine. Their reaction leads to the formation of 1-phenyl-3-methylpyrazolone-5 (3.2.9). Methylation of this product with methyl iodide gives 1-phenyl-... 

C7H6() 100-52-7) see Acetorphan Amphetaminil Atorvastatin calcium Azimilide hydrochloride Benzathine benzylpenicillin Docetaxel L(-)-Ephedrine Ethotoin Fenipentol Fenquizone Furazolidone Imolamine Isocarboxazid Metamizole sodium Oxacillin Paclitaxel Phensuximide Phentermine Pildralazine Propiverine benzaldehyde [6-[(2-hydroxypropyl)methylamino]-3-py-ridazinyl]hydrazone... 

Pyrazolone compounds with pharmaceutical applicability are, in UV spectrophotometry, a relatively limited, clearly defined group in which phenylbutazone [701] can be included. They are characterised by 2 relatively broad maxima with different wavelengths and intensities, 234-246 nm and 265-275 nm (see figure 7). In the base-substituted compounds (dimethylamino phenazone [103], metamizole sodium [109]) in acid solution the longwave maximum occurs at approximately the point of the minimum in methanol solution. The curves are slightly flattened in alkaline solution. is around 10000 in methanolic solution. 

Pyrazolone derivatives Azapropazone, Feprazone, Kebuzone, Metamizole sodium (Dipyrone), Oxyphenbutazone, Phenylbutazone... 

The concurrent use of 20 mL of Maaloxan (aluminium/magnesium hydroxide gel) was reported to have had no effect on the pharmacokinetics of the metabolites of metamizole sodium. ... 

A study in untreated patients with leprosy showed that the pharmacokinetics of a single 600-mg dose of rifampicin were not markedly changed by 1 g of metamizole sodium (dipyrone), but peak serum rifampicin levels occurred sooner (at 3 instead of 4 hours) and were about 50% higher. ... 

One report claims that metamizole sodium does not interact with phenprocoumon or ethyi biscoumacetate, whereas another describes a rapid but transient increase in the effects of ethyl biscoumacetate. Aii NSAIDs increase the risk of gastrointestinal bleeding, and an increased risk is seen when they are combined with anticoaguiants. 

A single 1-g dose of metamizole sodium did not alter the steady-state anticoagulant effeets of either phenprocoumon (5 subjects) or ethyl biscoumacetate (6 subjects). Conversely, another report describes a short-lived but rapid increase (within 4 hours) in the effects of ethyl biscoumacetate caused by single 1-g dose metamizole sodium. The reasons are not understood. However, care is still needed with every NSAID , (p.427), because, to a greater or lesser extent, they irritate the stomach lining, which... 

A study in a patient with osteosarcoma found that metamizole sodium 4 g daily more than doubled the methotrexate AUC during the first cycle of high-dose methotrexate treatment. ... 

A study in 9 healthy subjects found that metamizole sodium 3 g daily for 3 days, reduced the clearance of intravenous furosemide 20 mg from 175 to 141 mL/minute but the diuretic effects of the furosemide were unchanged. 

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