Metallothionein cadmium related

Pseudomonas putida growing on 3 mM cadmium synthesizes three cysteine-rich proteins of molecular weight 4000 to 7000, containing four to seven cadmium, zinc and copper atoms per molecule. The use of I13Cd NMR on the major cadmium protein shows it to be related to cadmium metallothionein, but with some significant differences.I223b... 

Some causal relations among various urinary indices were identified using path analysis method. Cadmium-induced renal dysfunction develops in the following order Cd exposure —> increased p2-microglobulin and/or metallothionein —> increased excretion of amino-nitrogen and/or total protein —> increased excretion of glucose [76]. 

In mammalian cells, some proteins combine with specific metals which are called metal proteins. For instance, transferrin is an iron carrier, ferritin can store iron [9], metallothionein (MT) can hold divalent metals such as zinc, copper, cadmium and so on [10, 11]. In chromosomes, there are some regions where metal proteins combine and regulate gene expressions. Zinc-finger motif proteins are famous for regulating transcriptimi and translation [12]. These metal-related... 

Waalkes et al. 1991a), indicating a genetic basis of susceptibility. It has been concluded from other mechanistic studies that the susceptibility of some tissues, e.g., testes and prostate, to cadmium carcinogenesis may be related to the relative lack of metallothionein in these tissues (Waalkes et al. 1989, 1992a, 1993a), which would reduce the capacity of these tissues to detoxify cadmium. 

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