Metabolomics engineering

Kristensen C, Morant M, Ollsen CE, Ekstrom CT, Galbraith DW, MoUer BL, Bak S. (2005). Metabolic engineering of dhurrin in tiansgenetic Arabidopsis plants with marginal inadvertent effects on metabolome and transcrip tome. Proceedings of the National Academy of Sciences, 102,... 

Kristensen, C., Morant, M., Olsen, C.E., Ekstrom, C.T., Galbraith, D.W., Mailer, B.L., and Bak, S. (2005) Metabolic engineering of dhurrin in transgenic Arabidopsis plants with marginal inadvertent effects on the metabolome and transcriptome. PNAS -Proc. Natl. Acad. Sci, 102,1779-84. 

S. (2007) Lessons learned from metabolic engineering of cyanogenic glucosides. Metabolomics, 3, 383-98. 

Science (microbial community genomics microbial in situ bioremediation proteomics and metabolomics PCR and revolutions in microbiology (6) engineering (bioprocessing, biotechnology, combining unit operations) (2)... 

The representation of each substance at an atomic rather than a molecular level allows focus on structural elements of each metabolite. Results of automated pathway reconstruction are based on computed movements in the location of each atom by the tracing engine of the software. The construction of a mapping database, which enables atomic tracers and search functions for certain structural elements, serves to close the gap between pathway databases and computer simulations. Though the coverage of the mapping database is important for reliable reconstruction, once a reasonable set of metabolome data from secondary metabolism is obtained, hypothetical pathways and relationships can be computed... 

Metabolomics is an extension of proteomics and describes the analysis of the catalytic activities that make up the metabolic activities of a cell. Metabolomics is at the core of biosystems engineering and its purpose is to analyze the metabolome (all metabolites, roughly in the range of 500- 2000) and their concentrations in the cell under given physiological conditions, as well as the dynamic response to changing environmental conditions (notably in a bioreactor). 

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