Metabolomics and Fluxomics

Kromer JO, Sorgenfrei O, Klopprogge K et al (2004) In-depth profiling of lysine-producing Corynebacterium glutamicum by combined analysis of the transcriptome, metabolome, and fluxome. J Bacteriol 186 1769-1784... 

Lysine Glucose Systems biology profiling of a production process with transcriptome, metabolome, and fluxome analysis [76]... 

Proteomics and metabolomics detect only a small subset of the total proteome and metabolome, and fluxomics (metabolic flux analysis) tends to focus on discrete pathways determined in part by the substrates that are used for the analysis. To date, gel-based proteomic analysis ranains... 

It is helpful to consider cellular activities in terms of a hierarchy that collectively provides a framework within which the various levels of function can be viewed as an ordered whole. These are the genome, the transcriptome, the metabolome and the fluxome (Figure 4.2). 

Metabolome represents the entire set of low-molecular-weight metabolites that are present in a cell and/or outside the cell under particular conditions [30]. Metabolite profiling allows comparative analysis of physiological states under different conditions e.g., a wild-type vs its mutants, and different culture conditions. Fluxome, the entire set of metabolic fluxes, can also be used for understanding the cellular... 

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