Metabolite amino-acid-derived

One may, therefore, assume that the lactam metabolites formed are rather resistant to hydrolytic degradation and do not contribute significantly to the formation of the co-amino acid derivatives. This is in line with the observation that substituted pyrrolidin-2-ones are generally resistant to metabolic hydrolysis (see Sect. 5.3). 

Fig. 5.26. Metabolism of the piperidine ring according to the mechanism in Fig. 5.23. Diphen-idol (5.97) and DN-9893 (5.73) yield both amino acid and lactam metabolites [177], Phencyclidine (5.98) yields only the amino acid derivative steric hindrance at the N-atom appears to impede formation of the lactam metabolite [190].

Structure and Function of Peptidyl Carrier Protein Domains Structure and Function of Adenylation Domains Structure and Function of Condensation Domains Structure and Function of Thioesterase Domains Multidomain NRPS Structural Information PCP-C didomain structure PCP-TE didomain structure Structure of a C-A-PCP-TE termination module Pathways to Nonproteinogenic Amino Acids Incorporated into NRP Natural Nonproteinogenic Amino Acids Present as Cellular Metabolites Modification of Proteinogenic Amino Acids Nonproteinogenic Amino Acids Derived from Multistep Pathways Tailoring Enzymology in NRP Natural Products Chemical Approaches Toward Mechanistic Probes and Inhibitors of NRPS... 

The dysideathiazoles A-E (331-335) are a series of polychlorinated amino acid derivatives from Pacific Island collections of D. herbacea. The structures were determined by X-ray analyses and the absolute configurations were determined by X-ray crystallography of a brominated derivative [301]. Herbamide A (336), a chlorinated amide was isolated from a Papua New Guinean sample of D. herbacea as a minor component [302]. D. herbacea from the southern Great Barrier Reef contained a thiazole (337) amongst other known metabolites [303]. A Dysidea sp. 

Alitame is an amino acid derivative and, therefore, not completely stable. It does hydrolyse in acid conditions, but is more stable than aspartame under certain conditions (Pfizer, 1987). Alitame is partially metabolised and absorbed in humans and is excreted as a mixture of its metabolites and unchanged alitame (Pfizer, 1987). 

The chemistry of the subclass Zoantharia also shows significant deviation from the Octocorallia. Of 151 zoantharian metabolites reported, 88 (58%) are derived from the amino acid pathway. Zoanthids (order Zoanthidea) contain a high proportion of amino acid derivatives (46, 75%), the... 

Davidson, B. S., Ascidians producers of amino acid derived metabolites, Chem. Rev., 93, 1771, 1993. 

The tunichromes constitute a class of amino-acid-derived metabolites isolated from the blood cells of ascidians. The chemicals are involved in vanadium sequestration and reduction in the blood cells and may be involved in a primitive clotting mechanism to repair damaged tissue.226-227 The... 

The metabolites of dimethyldithiocarbamid acid play a part in the systemic aqtion of plants (Dekhuijzen, 1964). Pluijgers et al. (1969) erefore synthesised several carbohydrate and amino acid derivatives of dimethyidithiocarbamic acid. 

This approach was considered because it would permit the synthesis of biomaterials (for drug delivery systems, sutures, artificial organs, etc.) which are derived from nontoxic metabolites (amino acids and dipeptides) while also having other desirable properties for example, the incorporation of an anhydride linkage into the polymer backbone could result in rapid biodegradability, an iminocarbonate bond may provide mechanical strength, and an ester bond may result in better film and fiber formation. 

Tunicates (ascidians) are an excellent source of novel biologically active compounds of varied biosynthetic origin, particularly nitrogen-containing amino-acid-derived metabolites [146], The most important compounds discovered to date from tunicates may be the didemnins, potent cytotoxic and antiviral cyclic... 

Wang, Y. Gloer, J.B. Scott, J.A. Malloch, D. "Terezines A-D new amino acid-derived bioactive metabolites from the coprophilous fungus Sporormiella teretispora", J. Nat. Prod., 1995, 55(1), 93-99. 

Ascidians Producers of Amino Acid Derived Metabolites. Davidson B. Chem. Rev. 1993,93, 1771. 

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