Amino Acid Derived Metabolites from Porifera

Amino Acid Derived Metabolites from Porifera 

In an effort to compare the halogenated tyrosine derivatives from Desmospongiae Makarieva et al. (149) investigated 22 species of eleven Demospongiae families and identified 10 substances of this type in Aplysina (Verongia), Verongula, and Aiolochroia species. It has been shown that animals of the Aplysinidae family biosynthesize all three forms [(-I-), (—), (+) = racemate] of aeroplysinin-1 (233) and of an 

Compound 254 was cytotoxic in vitro (KB cells), the effective dose 

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Amino Acid Derived Metabolites from Porifera.183... 

Metabolites of the phylum Porifera account for almost 50% of the natural products reported from marine invertebrates. Of the 2609 poriferan metabolites, 98% are derived from amino acid, acetogenin, or isoprenoid pathways. Isoprenoids account for 50% of all sponge metabolites, while amino acid and polyketide pathways account for 26% and 22%, respectively. A significant number of sponge metabolites appear to be derived from mixed biosynthetic pathways. Most structures reported containing carbohydrate moieties were glycosides. 

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