Metabolic Syndrome oxidative stress

Frisard, M. and Ravussin, E., (2006). Energy metabolism and oxidative stress impact on the metabolic syndrome and the aging process. Endocrine 29,27-32. 

Cross, C.E., Forte, T., Stocker, R., Louie, S., Yamamoto, Y., Ames, B.N. and Frei, B. (1990). Oxidative stress and abnormal cholesterol metabolism in patients with adult respiratory distress syndrome. J. Lab. Clin. Med. 115, 396-404. 

Broncel, M. Kozirog, M. Duchnowicz, P. Koter-Michalak, M. Sikora, J. Chojnowska-Jezierska, J. 2010. Aronia melanocarpa extract reduces blood pressure, serum endothelin, lipid, and oxidative stress marker levels in patients with metabolic syndrome. Med. Sci. Monit. 16 CR28-34. 

Fortune, A., San Jose, G., Moreno, M. U., Beloqui, O., Diez, J., Zalba, G. (2006). Phagocytic NADPH oxidase overactivity underlies oxidative stress in metabolic syndrome. Diabetes, 55, 209-215. 

Oxidative stress can be caused by a wide variety of factors, including inflammatory responses to infections or immune activation, exposure to heavy metals or toxic substances (Carpenter et al., 2002), and oxidative stress increases during the natural course of aging (Junqueira et al., 2007). When oxidative stress is induced by environmental exposures it represents a significant component of the toxicity syndrome, and most xenobiotics share the ability to cause oxidative stress. As a consequence, the effects of multiple exposures are additive at the level of oxidative stress. Metabolic changes associated with oxidative stress can be considered to be adaptive responses that increase prospects for survival during these stressful episodes. 

Riekse RG, Li G, Petrie EC, Leverenz JB, Vavrek D, Vuletic S, Albers JJ, Montine TJ, Lee VM, Lee M, Seubert P, Galasko D, Schellenberg GD, Hazzard WR, Peskind ER (2006) Effect of statins on Alzheimer s disease biomarkers in cerebrospinal fluid. J Alzheimer Dis 10 399-406 Ridha BH, Josephs KA, Rosser MN (2005) Delusions and hallucinations in dementia with Lewy bodies worsening with memantine. Neurology 65 481 82 Roberts CK, Barnard RJ, Sindhu RK, Jurczak M, Ehdaie A, Vaziri ND (2006) Oxidative stress and dysregulation of NAD(P)H oxidase and antioxidant enzymes in diet-induced metabolic syndrome. Metabolism 55 928—934... 

Hansel, B., Giral, P, Nobecourt, E., Chantepie, S., Bruckert, E., Chapman, M.J., and Kontush, A., Metabolic syndrome is associated with elevated oxidative stress and dysfunctional dense high-density lipoprotein particles displaying impaired antioxidative activity, J. Clin. Endocrinol. Metab., 89,4963-4971, 2004. 

Association of Oxidative Stress and Lipids with Risk Factors of Metabolic Syndrome... 

Cicogna, A.C., and NoveUi, E.L.B. Monosodium glutamate in standard and high-fiber diets Metabolic syndrome and oxidative stress in rats, 2005 21(6) 749-55. 

Diana L.-C., Karla C., Danira T.-R. Diana Franco-Bocanegra, and Victoria Campos— Pena Oxidative Stress and Metabolic Syndrome Cause or Consequence of Alzheimer s Disease Oxidative Med. Cell. Longevity 2014 2014 1-11. 

ROLE OF CARBONYL/OXIDATIVE STRESS ON THE PATHOGENESIS OF CHRONIC KIDNEY DISEASE AND THE METABOLIC SYNDROME... 

Is oxidative/carbonyl stress playing a physiological role in human, and could carbonyl substances be a marker of CKD and metabolic syndrome To answer this question we have recently determined urinary markers of oxidative and carbonyl stress in young adults (unpublished observation). In young male adults of BMI level of 30 and above, Na consumption is associated with systolic blood pressure, which was accompanied with higher urinary MGO and albumin excretion. In diabetes patients, plasma level of MGO in diabetes predicted 5 year progression of hypertension and intima media thickness of carotid artery (Unpublished observation). 

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