Metabolic screening, mass spectrometry

RASHED, M.S., BUCKNALL, M.P., LITTLE, D., AWAD, A., JACOB, M., ALAMOUDI, M., ALWATTAR, M., OZAND, P.T., Screening blood spots for inborn errors of metabolism by electrospray tandem mass spectrometry with a microplate batch process and a computer algorithm for automated flagging of abnormal profiles, Clin. Chem., 1997,43,1129-1141. [Pg.79]

Korfmacher, W. A. et al. 1999. Development of an automated mass spectrometry system for the quantitative analysis of liver microsomal incubation samples A tool for rapid screening of new compounds for metabolic stability. Rapid Commun. Mass Spectrom. 13 901. [Pg.243]

Koeberl DD, Young SP, Gregersen NS, Vockley J, Smith WE, Benjamin DK Jr, An Y, Weavil SD, Chaing SH, Bah D, McDonald MT, Kishnani PS, Chen YT, Millington DS. Rare disorders of metabolism with elevated butyryl- and isobutyryl-carnitine detected by tandem mass spectrometry newborn screening. Pediatr Res. 2003 Aug 54(2) 219-23. Epub 2003 May 7. PubMed citation... [Pg.7]

J. W. Hirschelman, W. H. et ah Increasing the throughput and productivity of Caco-2 cell permeability assays using liquid chromatography-mass spectrometry application to resveratrol absorption and metabolism. Comb Chem High Throughput Screen 2003, 6, 757-767. [Pg.422]

The balance between renal clearance and metabohsm is readily predicted by physicochemical properties [36]. Rate of metabolism and formation of metabolic products can be screened for, using Ever microsomal systems and mass spectrometry. The... [Pg.137]

Schulze A, Lindner M, Kohlmuller D, Olgemoller K, Mayatepek E, Hoffmann GF (2003) Expanded newborn screening for inborn errors of metabolism by electrospray ionization - tandem mass spectrometry results, outcome, and implications. Pediatrics 111 1399-1406... [Pg.90]

Pitt JJ, Eggington M, Kahler SG (2002) Comprehensive screening of urine samples for inborn errors of metabolism by electrospray tandem mass spectrometry. Clin Chem 48 1970-1980... [Pg.168]

Millington DS, Kodo N, Norwood DL, Roe CR (1990) Tandem mass spectrometry a new method for acylcarnitine profiling with potential for neonatal screening for inborn errors of metabolism. J Inherit Metab Dis 13 321-324... [Pg.204]

Koeberl DD, Young SP, Gregersen NS, et al (2003) Rare disorders of metabolism with elevated butyryl- and isobutyryl-carnitine detected by tandem mass spectrometry newborn screening. Pediatr Res 54 219-223... [Pg.205]

Screening for Disorders of Purine and Pyrimidine Metabolism Using HPLC-Electrospray Tandem Mass Spectrometry... [Pg.725]

Ito T, van Kuilenburg ABP, Bootsma AH, Haasnoot AJ, van Cruchten AG, Wada Y, van Gen-nip AH (2000) Rapid screening of high-risk patients for disorders of purine and pyrimidine metabolism using HPLC-electrospray tandem mass spectrometry of liquid urine or urine-soaked filter paper strips. Clin Chem 46 445-452... [Pg.736]

Mortishire-Smith, R. J., O Connor, D., Castro-Perez, J. M., and Kirby, J. (2005). Accelerated throughput metabolic route screening in early drug discovery using high-resolution liquid chromatography/quadrupole time-of-flight mass spectrometry and automated data analysis. Rapid Commun. Mass Spectrom. 19 2659-2670. [Pg.188]

Mass spectrometry (MS) is playing an increasingly visible role in the molecular characterization of combinatorial libraries, natural products, drug metabolism and pharmacokinetics, toxicology and forensic investigations, and proteomics. Toward this end, electrospray ionization (ESI), atmospheric pressure chemical ionization (APCI), and atmospheric pressure photo-ionization (APPI) have proven valuable for both qualitative and quantitative screening of small molecules (e.g., pharmaceutical products) [9-14]. [Pg.606]

The advantages of pulsed ultrafiltration-mass spectrometry include the variety of different applications that may be carried out, the convenience of on-line screening, solution-phase screening, the ability to screen either combinatorial libraries or natural product extracts, the diversity of receptors that may be screened, and the freedom to use either volatile or non-volatile binding buffers. For metabolic and toxicity screening, flow injection analyses have the additional advantages that product feedback inhibition is prevented so that the metabolic profile more closely approximates the in vivo system ( 70). Finally, the... [Pg.606]

Tandem mass spectrometry (MS/MS) is applicable to the rapid assay of specific analytes in complex biological fluids (see Chapter 7). In practice, it is usually interfaced to a GC or LC. MS/MS has been used to screen neonates for such amino acid metabolic disorders... [Pg.541]

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