Metabolic Activation of Hepatotoxicants

Studies of liver toxicity caused by bromobenzene, acetaminophen, and other compounds have led to some important observations concerning tissue damage  

These same principles are applicable to the toxicity caused by reactive metabolites in other organs, such as kidney and lung as will be illustrated in the following sections. 

Hodgson, E., and S. A. Meyer. Pesticides. In Comprehensive Toxicology Hepatic and Gastrointestinal Toxicology, vol. 9, I. G. Sipes, C. A. McQueen, and A. J. Gandolfi, eds. New York Elsevier Science, 1997, p. 369. 

Mechanisms of chemically induced cell injury and cellular protection mechanisms. In An Introduction to Biochemical Toxicology, 3rd ed., E. Hodgson and R. C. Smart, eds. New York Wiley, 2001, p. 221. 

Treinen-Moslen, M. Toxic responses of the liver. In Casarett and Doull s Toxicology The Basic Sciences of Poisons, 6th ed., C. D. Klaassen, ed. New York McGraw-Hill, 2001, p. 471. 

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