Mescaline reward

There are other distinctions from mescaline. Unlike mescaline or Peyote, there is rarely any body discomfort during the early phase of intoxication, no nausea and only an occasional comment suggesting hyperreflexia. And, also unlike mescaline, most subjective reports on ME claim that music produces little imagery, and the exaggeration of color perception is more reserved. Appetite is normal, the tastes and textures of food are unusually rewarding. No subject has ever expressed a reluctance to repeat the experience. Sleep is easy, refreshing, and the following day seems free from residue. 

Interestingly, the natural hallucinogens, such as peyote and mescaline (and nearly all other hallucinogens) do not engender compulsive drug seeking or addiction, nor do they lead to chemical dependence. Part of the reason is that these compounds do not stimulate the dopaminergic reward center in the brain, as they lack affinity for the dopamine receptor and the dopamine uptake transporter. 

---